C₁₉H₂₁N₃O₄S

Base Information

Chemical Name:C₁₉H₂₁N₃O₄S
CAS No.:1352536-81-2
Molecular Formula:C₁₉H₂₁N₃O₄S
Molecular Weight:387.459
Hs Code.:

C<sub>19</sub>H<sub>21</sub>N<sub>3</sub>O<sub>4</sub>S

Synonyms:C₁₉H₂₁N₃O₄S

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Chemical Property of C₁₉H₂₁N₃O₄S

Chemical Property:

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Technology Process of C₁₉H₂₁N₃O₄S

There total 6 articles about C₁₉H₂₁N₃O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1352536-81-2
C₁₉H₂₁N₃O₄S

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

3.1: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: thionyl chloride / toluene / 2 h / Inert atmosphere; Reflux

5.1: dichloromethane / 20 °C / Inert atmosphere

6.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

6.3: 20 °C / Inert atmosphere

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.10.022

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 1352536-81-2
C₁₉H₂₁N₃O₄S

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / toluene / 2 h / Inert atmosphere; Reflux

4.1: dichloromethane / 20 °C / Inert atmosphere

5.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

5.3: 20 °C / Inert atmosphere

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.10.022

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1352536-81-2
C₁₉H₂₁N₃O₄S

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydroxide / ethanol; water / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / toluene / 2 h / Inert atmosphere; Reflux

4.1: dichloromethane / 20 °C / Inert atmosphere

5.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

5.3: 20 °C / Inert atmosphere

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.10.022