Benzenemethanol, 2-amino-3-methoxy- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 2-amino-3-methoxy- (9CI)
• CAS No.: 205877-13-0
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.181
• Hs Code.: 2922509090
• Mol file: 205877-13-0.mol

Synonyms:Benzenemethanol, 2-amino-3-methoxy- (9CI)

Chemical Property of Benzenemethanol, 2-amino-3-methoxy- (9CI)

Chemical Property:

• Melting Point: 38 °C
• Boiling Point: 312.6±27.0 °C(Predicted)
• PKA: 14.28±0.10(Predicted)
• PSA: 55.48000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 1.35090

Purity/Quality:

97% ^*data from raw suppliers

(2-Amino-3-methoxyphenyl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 2-amino-3-methoxy- (9CI)

There total 4 articles about Benzenemethanol, 2-amino-3-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-3-methoxybenzoic acid (3177-80-8) → (2-amino-3-methoxyphenyl)methanol (205877-13-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 1.66667h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

Reference yield:

(3-methoxy-2-nitrophenyl)methanol (53055-04-2) → (2-amino-3-methoxyphenyl)methanol (205877-13-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 1h; under 760 Torr;

DOI:10.1021/jm00063a014

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → (2-amino-3-methoxyphenyl)methanol (205877-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: B₂H₆ / tetrahydrofuran

2: H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

With hydrogen; diborane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jm00063a014

upstream raw materials:

(3-methoxy-2-nitrophenyl)methanol

2-amino-3-methoxybenzoic acid

3-methoxy-2-nitrobenzoic acid

Downstream raw materials:

1-(2-Hydroxymethyl-6-methoxy-phenyl)-3-pentyl-urea

4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

(-)-Mianserin

1-(2-Hydroxy-6-hydroxymethyl-phenyl)-3-pentyl-urea