(1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one

Base Information

• Chemical Name: (1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one
• CAS No.: 120240-00-8
• Molecular Formula: C₁₉H₂₁NO₂
• Molecular Weight: 295.381

Synonyms:(1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one

Chemical Property of (1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one

There total 1 articles about (1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.0^2,7]undec-6-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 3,5,6,7,8,8a-hexahydro-7,7,8a-trimethyl-<6S-(6α,8α,8αβ)>-6,8-methano-2H-1,4-benzoxazin-2-one (120239-95-4) → (1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.02,7]undec-6-en-4-one (120240-00-8)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1.) THF, -78 deg C, 45 min, 2.) THF, -80 deg C;

DOI:10.1016/S0957-4166(00)80263-3

Reference yield: 68.0%

(1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.02,7]undec-6-en-4-one (120240-00-8) → (3S,6S,8S,8aS)-3-benzyl-7,7,8a-trimethyl-3,5,6,7,8,8a-hexahydro-2H-6,8-methanobenzo[b][1,4]oxazin-2-one (141895-40-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1016/S0957-4166(00)80263-3

Reference yield:

(1S,2S,9S)-2,10,10-Trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-3-oxa-6-aza-tricyclo[7.1.1.02,7]undec-6-en-4-one (120240-00-8) → L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / H₂ / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

2: 93 percent / 6 N HCl / tetrahydrofuran / 3 h / 70 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0957-4166(00)80263-3

upstream raw materials:

benzaldehyde

3,5,6,7,8,8a-hexahydro-7,7,8a-trimethyl-<6S-(6α,8α,8αβ)>-6,8-methano-2H-1,4-benzoxazin-2-one

Downstream raw materials:

(3S,6S,8S,8aS)-3-benzyl-7,7,8a-trimethyl-3,5,6,7,8,8a-hexahydro-2H-6,8-methanobenzo[b][1,4]oxazin-2-one

L-phenylalanine

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