N-pyridoxylidenephenylglycine methyl ester

Base Information

• Chemical Name: N-pyridoxylidenephenylglycine methyl ester
• CAS No.: 122886-29-7
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• Mol file: 122886-29-7.mol

Synonyms:N-pyridoxylidenephenylglycine methyl ester

Chemical Property of N-pyridoxylidenephenylglycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-pyridoxylidenephenylglycine methyl ester

There total 1 articles about N-pyridoxylidenephenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

pyridoxal hydrochloride (65-22-5) + DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7) → N-pyridoxylidenephenylglycine methyl ester (122886-29-7)

Guidance literature:

With potassium hydroxide; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86100-7

Reference yield: 79.0%

N-phenyl-maleimide (941-69-5) + N-pyridoxylidenephenylglycine methyl ester (122886-29-7) → methyl 2,7-diphenyl-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-2-carboxylate (122886-40-2)

Guidance literature:

In xylene; at 140 ℃; for 3.5h;

DOI:10.1016/S0040-4020(01)86100-7

Reference yield: 49.0%

(E)-3-(methoxycarbonyl)methylene-1,3-dihydroindol-2-one (105703-61-5) + N-pyridoxylidenephenylglycine methyl ester (122886-29-7) → (2'S,3'S,4'R,5'R)-2'-(3-Hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-yl)-2-oxo-5'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-4',5'-dicarboxylic acid dimethyl ester (122886-45-7)

Guidance literature:

In xylene; at 130 ℃; for 120h;

DOI:10.1016/S0040-4020(01)86100-7

upstream raw materials:

pyridoxal hydrochloride

DL-2-phenylglycine methyl ester hydrochloride

Downstream raw materials:

methyl 2,7-diphenyl-4-(3'-hydroxy-5'-hydroxymethyl-2'-methyl-4'-pyridyl)-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-2-carboxylate

(2'S,3'S,4'R,5'R)-2'-(3-Hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-yl)-2-oxo-5'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-4',5'-dicarboxylic acid dimethyl ester