4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

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Chemical Name:4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile
CAS No.:1430210-58-4
Molecular Formula:C₂₉H₂₈FN₃O₃S
Molecular Weight:517.624
Hs Code.:

Synonyms:4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

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Chemical Property of 4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

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Technology Process of 4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

There total 10 articles about 4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 2-((2-bromoethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 767-00-0
4-cyanophenol

: 1430210-58-4
4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; for 5h; Temperature; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00323

Reference yield:

: 1-amino-3-(3, 4-dimethoxyphenyl)-3-methylbutan-2-one hydrobromide

: 1430210-58-4
4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: acetic acid / 3 h / 118 °C

3: acetone / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 70 °C / Inert atmosphere

With potassium carbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/acsmedchemlett.5b00323

Reference yield:

: 4461-99-8
3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one

: 1430210-58-4
4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetra-N-butylammonium tribromide / dichloromethane; methanol / 7 h / 0 - 20 °C

2.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

2.2: 3 h / 0 °C / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: acetic acid / 3 h / 118 °C

5.1: acetone / 2 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 70 °C / Inert atmosphere

With hexamethylenetetramine; tetra-N-butylammonium tribromide; potassium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 2.1: |Delepine Amine Synthesis / 2.2: |Delepine Amine Synthesis;
DOI:10.1021/acsmedchemlett.5b00323