rac 8-Hydroxy Efavirenz

Base Information

Chemical Name:rac 8-Hydroxy Efavirenz
CAS No.:205754-32-1
Molecular Formula:C₁₄H₉ClF₃NO₃
Molecular Weight:331.679
Hs Code.:
DSSTox Substance ID:DTXSID201043213
Nikkaji Number:J1.525.086K
ChEMBL ID:CHEMBL4645070
Mol file:205754-32-1.mol

Synonyms:rac 8-Hydroxy Efavirenz;205754-32-1;ent-8-Hydroxy Efavirenz;CHEMBL4645070;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-;6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-8-HYDROXY-4-(TRIFLUOROMETHYL)-1H-3,1-BENZOXAZIN-2-ONE;6-Chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one;starbld0009374;SCHEMBL1152018;8-Hydroxy Efavirenz (~90%);OOVOMPCQLMFEDT-UHFFFAOYSA-N;DTXSID201043213;BDBM50540110;PD117322;FT-0669576;J-013429;4-(Trifluoromethyl)-4-(cyclopropylethynyl)-6-chloro-8-hydroxy-1,2-dihydro-4H-3,1-benzoxazine-2-one;6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Suppliers and Price of rac 8-Hydroxy Efavirenz

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac8-HydroxyEfavirenz
10mg
$ 1455.00

TRC
rac8-HydroxyEfavirenz
5mg
$ 845.00

TRC
rac8-HydroxyEfavirenz
1mg
$ 185.00

Medical Isotopes, Inc.
rac8-HydroxyEfavirenz
1 mg
$ 390.00

American Custom Chemicals Corporation
RAC 8-HYDROXY EFAVIRENZ 95.00%
10MG
$ 1732.50

American Custom Chemicals Corporation
RAC 8-HYDROXY EFAVIRENZ 95.00%
1MG
$ 721.88

Total 6 raw suppliers

Chemical Property of rac 8-Hydroxy Efavirenz

Chemical Property:

Vapor Pressure:4.13E-06mmHg at 25°C
Melting Point:186-188?C
Refractive Index:1.608
Boiling Point:373.6°C at 760 mmHg
Flash Point:179.7°C
PSA：58.56000
Density:1.64g/cm³
LogP:3.91670
Storage Temp.:-20°C Freezer
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:331.0223053
Heavy Atom Count:22
Complexity:551

Purity/Quality:

98%Min ^*data from raw suppliers

rac8-HydroxyEfavirenz ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1C#CC2(C3=C(C(=CC(=C3)Cl)O)NC(=O)O2)C(F)(F)F
Uses A metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor A metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

Technology Process of rac 8-Hydroxy Efavirenz

There total 24 articles about rac 8-Hydroxy Efavirenz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 8-mesyloxy-efavirenz

: 205754-33-2,342621-26-5,205754-32-1
8-Hydroxyefavirenz

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.8b09208

Reference yield: 9.5%

: 154598-52-4,154635-17-3
efavirenz

: 205754-33-2,342621-26-5,205754-32-1
8-Hydroxyefavirenz

Guidance literature:: With N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamineiron(II) bis(triflate); dihydrogen peroxide; acetic acid; In ethyl acetate; acetonitrile; at 40 ℃; for 72h;
DOI:10.1039/c2ob25212k