(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

Base Information

Chemical Name:(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate
CAS No.:1401454-77-0
Molecular Formula:C₁₈H₂₃NO₆
Molecular Weight:349.384
Hs Code.:

Synonyms:(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

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Chemical Property of (2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

Chemical Property:

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Technology Process of (2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

There total 4 articles about (2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1401454-76-9
(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(hydroxymethyl)-aziridine-1-carboxylate

: 98-88-4
benzoyl chloride

: 1401454-77-0
(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1021/jo3015853

Reference yield:

: 1401454-74-7
C₂₁H₄₅NO₄Si₂

: 1401454-77-0
(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2: amano lipase PS / tetrahydrofuran; hexane / 3 h / 20 - 37 °C / Enzymatic reaction

3: dmap; triethylamine / dichloromethane / 0.33 h / 0 °C

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo3015853

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1401454-77-0
(2S,3R)-tert-butyl 2-(acetoxymethyl)-3-(benzoyloxymethyl)-aziridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.17 h / 0 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: amano lipase PS / tetrahydrofuran; hexane / 3 h / 20 - 37 °C / Enzymatic reaction

4: dmap; triethylamine / dichloromethane / 0.33 h / 0 °C

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo3015853