C₂₈H₃₂F₃N₅O₃

Base Information

Chemical Name:C₂₈H₃₂F₃N₅O₃
CAS No.:1566584-83-5
Molecular Formula:C₂₈H₃₂F₃N₅O₃
Molecular Weight:543.589
Hs Code.:

C<sub>28</sub>H<sub>32</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:C₂₈H₃₂F₃N₅O₃

Suppliers and Price of C₂₈H₃₂F₃N₅O₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₂₈H₃₂F₃N₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₂₈H₃₂F₃N₅O₃

There total 12 articles about C₂₈H₃₂F₃N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1566584-82-4
2-(2-(2-(2-(4-(1-(tert-butoxycarbonylamino)ethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

: 1566584-83-5
C₂₈H₃₂F₃N₅O₃

Guidance literature:: 2-(2-(2-(2-(4-(1-(tert-butoxycarbonylamino)ethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃;

Reference yield:

: 1566544-45-3
tert-butyl (1-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)ethyl)carbamate

: 1566584-83-5
C₂₈H₃₂F₃N₅O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3.1: lithium hydroxide / water; tetrahydrofuran / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

4.2: 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1566584-80-2
methyl 2-(2-((2-(4-(1-(tert-butoxycarbonylamino)ethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

: 1566584-83-5
C₂₈H₃₂F₃N₅O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

2.1: lithium hydroxide / water; tetrahydrofuran / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 40 °C

With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;