3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

Base Information

Chemical Name:3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one
CAS No.:1448520-17-9
Molecular Formula:C₂₀H₂₅NO₅
Molecular Weight:359.422
Hs Code.:

Synonyms:3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

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Chemical Property of 3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

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Technology Process of 3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

There total 4 articles about 3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3535-33-9
4-isopropyloxy-3-methoxybenzoic acid

: 1448520-17-9
3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 20 - 40 °C

2.1: sodium hydroxide / water; toluene / 0 °C / Inert atmosphere

3.1: iso-butanol / 20 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

With thionyl chloride; sodium hydroxide; In dichloromethane; water; toluene; iso-butanol;

Reference yield:

: 3535-39-5
4-isopropoxy-3-methoxybenzoyl chloride

: 1448520-17-9
3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; toluene / 0 °C / Inert atmosphere

2.1: iso-butanol / 20 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

With sodium hydroxide; In water; toluene; iso-butanol;

Reference yield:

: 7368-78-7
4-bromoguaiacol

: 1448520-17-9
3-(4-isopropoxy-3-methoxybenzoyl)-11-oxa-3-azaspiro[5.5]undec-9-en-8-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 20 - 55 °C

2.1: tert.-butyl lithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C / Inert atmosphere

3.1: thionyl chloride / dichloromethane / 20 - 40 °C

4.1: sodium hydroxide / water; toluene / 0 °C / Inert atmosphere

5.1: iso-butanol / 20 °C / Inert atmosphere

5.2: 0.5 h / -78 °C

With thionyl chloride; tert.-butyl lithium; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene; iso-butanol;