1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone

Base Information

• Chemical Name: 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone
• CAS No.: 1402404-44-7
• Molecular Formula: C₂₀H₂₈O₂Si
• Molecular Weight: 328.527
• Mol file: 1402404-44-7.mol

Synonyms:1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone

Chemical Property of 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone

There total 4 articles about 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

triethylsilane (617-86-7) + 3-(3-phenylpropyl-2-yn-1-ylidene)-2,4-pentanedione (67082-95-5) → 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone (1402404-44-7)

Guidance literature:

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); Selectfluor; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol502018d

Reference yield: 78.0%

triethylsilane (617-86-7) + Phenylpropargyl aldehyde (2579-22-8) + acetylacetone (123-54-6,81235-32-7) → 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone (1402404-44-7)

Guidance literature:

With zinc(II) chloride; In neat (no solvent); at 60 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201501155

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 1-(2-methyl-5-(phenyl(triethylsilyl)methyl)furan-3-yl)ethanone (1402404-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; piperidine; magnesium sulfate / toluene / 30 °C / Inert atmosphere; Schlenk technique

2: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); Selectfluor / 1,2-dichloro-ethane / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With piperidine; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); magnesium sulfate; acetic acid; Selectfluor; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/ol502018d

upstream raw materials:

triethylsilane

Phenylpropargyl aldehyde

acetylacetone

3-(3-phenylpropyl-2-yn-1-ylidene)-2,4-pentanedione