(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol

Base Information

• Chemical Name: (2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol
• CAS No.: 1306615-79-1
• Molecular Formula: C₂₀H₃₂O₃Si
• Molecular Weight: 348.558
• Mol file: 1306615-79-1.mol

Synonyms:(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol

Chemical Property of (2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol

There total 1 articles about (2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E,E)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-5-(4-methoxy-phenyl)penta-2,4-dien-1-al (1227391-18-5) → (2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol (1306615-79-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;

DOI:10.1007/s11172-010-0359-x

Reference yield: 58.0%

(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol (1306615-79-1) → (1E,3Z)-6-tert-butyldimethylsilyloxy-4-methyl-1-(4-methoxyphenyl)hexa-1,3-diene (1306615-82-6)

Guidance literature:

(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol; With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; p-toluenesulfonyl chloride; In diethyl ether; hexane; at 0 ℃; for 2.5h; Inert atmosphere;

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; hexane; at -15 - 20 ℃; Inert atmosphere;

DOI:10.1007/s11172-010-0359-x

Reference yield:

(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol (1306615-79-1) → (1E,3Z)-6-tert-butyldimethylsilyloxy-4-methyl-1-(4-methoxyphenyl)hexa-1,3-diene (1306615-82-6) + C20H32O2Si (1306615-87-1) + C20H32O2Si

Guidance literature:

(2E,4E)-2-(2-tert-butyldimethylsilyloxyethyl)-5-(4-methoxyphenyl)penta-2,4-dien-1-ol; With sulfur trioxide pyridine complex; In tetrahydrofuran; at -15 - 0 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1007/s11172-010-0359-x

upstream raw materials:

(E,E)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-5-(4-methoxy-phenyl)penta-2,4-dien-1-al

Downstream raw materials:

(3Z,5E)-6-(4-methoxyphenyl)-3-methylhexa-3,5-dien-1-ol

(1E,3Z)-6-tert-butyldimethylsilyloxy-4-methyl-1-(4-methoxyphenyl)hexa-1,3-diene

C₂₀H₃₂O₂Si

(3Z,5E)-6-(4-methoxyphenyl)-3-methylhexa-3,5-dienal