Technology Process of (S)-tert-butyl (6,7-bis(benzyloxy)-2-thioxo-1,2,3,4-tetrahydroquinolin-3-yl)carbamate
There total 6 articles about (S)-tert-butyl (6,7-bis(benzyloxy)-2-thioxo-1,2,3,4-tetrahydroquinolin-3-yl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Lawessons reagent;
In
toluene;
at 85 ℃;
for 18h;
DOI:10.1021/ol400490s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 48.25 h / -40 - 65 °C
2.1: triethylamine / methanol / 20.25 h / 0 - 20 °C
3.1: sodium iodide; potassium carbonate / acetone / 1 h / 20 °C
3.2: 22 h / Reflux
4.1: nitric acid; acetic acid; acetic anhydride / 4 h / 15 °C
5.1: zinc; ammonium chloride / methanol; tetrahydrofuran / 2 h / 20 °C
5.2: 16 h / 50 °C
6.1: Lawessons reagent / toluene / 18 h / 85 °C
With
Lawessons reagent; thionyl chloride; nitric acid; acetic anhydride; potassium carbonate; ammonium chloride; acetic acid; triethylamine; sodium iodide; zinc;
In
tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1021/ol400490s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / methanol / 20.25 h / 0 - 20 °C
2.1: sodium iodide; potassium carbonate / acetone / 1 h / 20 °C
2.2: 22 h / Reflux
3.1: nitric acid; acetic acid; acetic anhydride / 4 h / 15 °C
4.1: zinc; ammonium chloride / methanol; tetrahydrofuran / 2 h / 20 °C
4.2: 16 h / 50 °C
5.1: Lawessons reagent / toluene / 18 h / 85 °C
With
Lawessons reagent; nitric acid; acetic anhydride; potassium carbonate; ammonium chloride; acetic acid; triethylamine; sodium iodide; zinc;
In
tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1021/ol400490s
