(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate
CAS No.:1338718-82-3
Molecular Formula:C₂₅H₃₁F₂N₇O₃S
Molecular Weight:547.629
Hs Code.:

Synonyms:(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

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Chemical Property of (R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

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Technology Process of (R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

There total 3 articles about (R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338718-75-4
(R)-tert-butyl 4-(5-(4-Cbz-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

: 1338718-82-3
(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Guidance literature:: With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; at 95 ℃; for 2h; Sealed vial; Inert atmosphere;

Reference yield:

: 1270034-25-7
5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid

: 1338718-82-3
(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / 95 °C / Sealed vial; Inert atmosphere

With cyclohexa-1,4-diene; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 1338718-05-0
(R)-benzyl 1-(4-amino-1-methyl-1H-pyrazol-5-yl)azepan-4-ylcarbamate

: 1338718-82-3
(R)-tert-butyl 4-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 24 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / 95 °C / Sealed vial; Inert atmosphere

With cyclohexa-1,4-diene; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; dichloromethane;