5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine
CAS No.:1233482-92-2
Molecular Formula:C₄₈H₆₅N₅O₁₁P₂S
Molecular Weight:982.085
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Suppliers and Price of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1233482-73-9
O-(1-hydroxybutyl)-O-(2-cyanoethyl)-N-morpholino phosphonothioate

: 104655-84-7
5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite

: 1233482-92-2
5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: With 1H-tetrazole; In acetonitrile; at 25 ℃; for 3h; Inert atmosphere;
DOI:10.1039/b9nj00692c

Reference yield:

: C₃₂H₃₉N₂O₆P

: 1233482-92-2
5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur / dichloromethane / 16 h / 25 °C / Inert atmosphere

2: acetic acid / water / 3 h / 25 °C / Inert atmosphere

3: 1H-tetrazole / acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-tetrazole; sulfur; acetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1039/b9nj00692c

Reference yield:

: C₃₂H₃₉N₂O₆PS

: 1233482-92-2
5'-O-(4,4'-dimethoxytrityl)-3'-O-[4-[(2-cyanoethyl)-N-morpholinophosphonothioyl]but-1-oxy]-(N,N-diisopropylamino)phosphinyl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water / 3 h / 25 °C / Inert atmosphere

2: 1H-tetrazole / acetonitrile / 3 h / 25 °C / Inert atmosphere

With 1H-tetrazole; acetic acid; In water; acetonitrile;
DOI:10.1039/b9nj00692c