(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride
CAS No.:1428847-14-6
Molecular Formula:C₂₉H₃₀Cl₂F₂N₂O₇*ClH
Molecular Weight:663.93
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

There total 5 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1428847-18-0
(S)-4-(2-(2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)amino) acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

: 1428847-14-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1428847-14-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 3 h

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5.1: hydrogenchloride / dichloromethane / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 60857-14-9
ethyl 2-(3',4'-dimethoxybenzylamino)acetate

: 1428847-14-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: hydrogenchloride / dichloromethane / 20 °C

With hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;