60857-14-9

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 459-73-4 GlyOEt*HCl 
• 105-36-2 ethyl bromoacetate 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 952340-14-6 ethyl 2-[N-(3',4'-dimethoxybenzyl)-2''-phenylacetamido]acetate 
• 868755-29-7 (3S)-1-(3,4-dimethoxybenzyl)-3-methyl-2,5-piperazinedione 
• 170707-43-4 3-Diazo-1-(3,4-dimethoxy-benzyl)-pyrrolidine-2,4-dione 
• 188028-91-3 C₃₆H₃₁N₃O₇ 
• 170707-38-7 C₃₆H₃₁N₃O₇ 
• 170707-32-1 6-N-(dimethoxybenzyl)-staurosporinone 
• 195708-85-1 1-(3,4-Dimethoxy-benzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1428847-15-7 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(N-(3,4-dimethoxybenzyl)methylsulfonamido)-acetoxy)ethyl)pyridine 1-oxide 
• 1428847-16-8 ethyl 2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)-amino)acetate 
• 1428847-14-6 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(3,4-dimethoxybenzylamino)acetoxy)-ethyl)pyridine 1-oxide hydrochloride 
• 1428847-18-0 (S)-4-(2-(2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)amino) acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide 
• 1428847-17-9 2-(tert-butoxycarbonyl(3,4-dimethoxybenzyl)amino)-acetic acid 
• 688750-84-7 ethyl 2-(N-(3,4-dimethoxybenzyl)-4-methylphenylsulfonamido)acetate 
• 952340-16-8 1-(3',4'-dimethoxybenzyl)-3-phenyl-4-trifluoromethanesulfonyl-1H-pyrrol-2(5H)-one 

Relevant academic research and scientific papers

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

Suzuki-Miyaura cross-coupling approach to 3,4-diaryl-3-pyrrolin-2-ones from tetramic acid triflates

A three-step approach to 4-aryl-3-phenyl-3-pyrrolin-2-ones from a readily available tetramic acid is described. The introduction of different aryl groups to the 4-position of the ring system was accomplished utilizing Suzuki-Miyaura cross-coupling reactio

QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS

The present invention is directed to certain quinoline and isoquinoline compounds that are PDElO inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Microwave-assisted synthesis of 2,5-piperazinediones under solvent-free conditions

A general, efficient and environmentally friendly procedure for the synthesis of 2,5-piperazinediones is described, involving the microwave irradiation of N-Boc dipeptide esters. Georg Thieme Verlag Stuttgart.