2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

Base Information

• Chemical Name: 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone
• CAS No.: 174562-97-1
• Molecular Formula: C₂₁H₁₉F₆N₃O₄
• Molecular Weight: 491.39

Synonyms:2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

Chemical Property of 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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Technology Process of 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

There total 12 articles about 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(isopropoxydimethylsilyl)-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-98-2) → 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-97-1)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 70 - 80 ℃; for 1.5h;

DOI:10.1248/cpb.47.360

Reference yield: 55.0%

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-formyl-2-hydroxy-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-96-0) → 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-97-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1248/cpb.47.360

Reference yield:

1N-hydrochloric acid + 2-<(1R,2S)-2-(2,4-difluorophenyl)-2-formyl-2-hydroxy-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-96-0) → 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-dihydroxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone (174562-97-1)

Guidance literature:

With sodium borohydrid; sodium chloride; In methanol; water; ethyl acetate;

upstream raw materials:

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-formyl-2-hydroxy-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-butenyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(isopropoxydimethylsilyl)-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

1,3-Difluorobenzene

Downstream raw materials:

2-<(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-methanesulfonyloxy-1-methylpropyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

2-<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

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