N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

Base Information

Chemical Name:N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide
CAS No.:75767-71-4
Molecular Formula:C₁₉H₂₅NO₂
Molecular Weight:299.413
Hs Code.:

Synonyms:N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

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Chemical Property of N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

Chemical Property:

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Technology Process of N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

There total 7 articles about N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 75767-70-3
C₁₄H₂₅NO₂

: 98-88-4
benzoyl chloride

: 75767-71-4
N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

Guidance literature:: With pyridine; In toluene; at 70 ℃;
DOI:10.1021/jo01314a062

Reference yield:

: 52475-64-6
ethyl-(1S,5R)-5-methyl-2-oxo-cyclopentanecarboxylate

: 75767-71-4
N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 7 steps

2: 1.) H₂; 2.) p-TsOH / Pd/C / 1.)EtOH, 1 atm, 25 deg C; 2.) toluene, reflux

3: LiAlH₄ / tetrahydrofuran / Heating

4: Et₃N / CH₂Cl₂ / 0 °C

5: 77 percent / Et₄NCl / dimethylsulfoxide / 72 h / 90 - 105 °C

6: 93 percent / LiAlH₄ / diethyl ether / 0.5 h / 25 °C

7: 80 percent / pyridine / toluene / 70 °C

With pyridine; lithium aluminium tetrahydride; tetraethylammonium chloride; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo01314a062

Reference yield:

: 75767-63-4,75767-64-5
(R)-3-Methyl-6-oxo-1,2,3,4,5,6-hexahydro-indene-3a-carboxylic acid ethyl ester

: 75767-71-4
N-[2-((3R,3aR,7aS)-3-Methyl-6-oxo-octahydro-inden-3a-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) H₂; 2.) p-TsOH / Pd/C / 1.)EtOH, 1 atm, 25 deg C; 2.) toluene, reflux

2: LiAlH₄ / tetrahydrofuran / Heating

3: Et₃N / CH₂Cl₂ / 0 °C

4: 77 percent / Et₄NCl / dimethylsulfoxide / 72 h / 90 - 105 °C

5: 93 percent / LiAlH₄ / diethyl ether / 0.5 h / 25 °C

6: 80 percent / pyridine / toluene / 70 °C

With pyridine; lithium aluminium tetrahydride; tetraethylammonium chloride; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo01314a062