2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Base Information

• Chemical Name: 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide
• CAS No.: 1022946-74-2
• Molecular Formula: C₂₂H₂₀ClFN₆O₂
• Molecular Weight: 454.891

Synonyms:2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Chemical Property of 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

There total 5 articles about 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide (959246-74-3) + 7-Amino-1,3,4,5-tetrahydro-2H-benzazepin-2-on (22245-92-7) → 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide (1022946-74-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 130 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

2-amino-3-fluoro-N-methyl-benzamide (1017789-26-2) → 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide (1022946-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 21 h / 100 °C

2: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; isopropyl alcohol;

DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide (1022946-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 0.25 h / 0 °C

2: 10% palladium on activated carbon; hydrazine hydrate / ethanol / 60 °C

3: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation

With hydrogenchloride; sulfuric acid; 10% palladium on activated carbon; nitric acid; hydrazine hydrate; In 1,4-dioxane; ethanol; isopropyl alcohol;

DOI:10.1016/j.bmcl.2010.11.045

upstream raw materials:

2-amino-3-fluoro-N-methyl-benzamide

2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

7-Amino-1,3,4,5-tetrahydro-2H-benzazepin-2-on

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1022946-74-2 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send