22245-92-7

Usage

Uses

Used in Pharmaceutical Industry:
7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one serves as a key building block for the development of pharmaceuticals, particularly in the creation of antipsychotic and antidepressant drugs. Its diverse biological activities make it an essential component in the design and synthesis of novel therapeutic agents targeting a range of neurological conditions.
Used as a Precursor in Organic Synthesis:
Beyond its direct application in medicine, 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is also utilized as a precursor in the synthesis of other organic compounds. Its structural properties allow for its incorporation into a variety of chemical reactions, contributing to the advancement of organic chemistry and the development of new chemical entities with potential applications across various industries.

InChI:InChI=1/C10H12N2O/c11-8-4-5-9-7(6-8)2-1-3-10(13)12-9/h4-6H,1-3,11H2,(H,12,13)

Upstream product

• 22246-45-3 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 3470-53-9 6-amino-1-tetralone 
• 1022954-85-3 6-aminotetralin-1-one oxime 
• 939043-29-5 (1E)-6-Amino-3,4-dihydro-1(2H)-naphthalenone oxime 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 3349-64-2 1-tetralone oxime 

Downstream Products

• 22344-77-0 7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on 
• 53841-99-9 7-Brom-1,3,4,5-tetrahydro-2H-benzazepin-2-on 
• 104479-35-8 4-(2,5-Diamino-4-nitro-phenyl)-butyric acid methyl ester 
• 1022946-74-2 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide 

Relevant academic research and scientific papers

NOVEL IMIDAZO-PYRAZINE DERIVATIVES

The invention provides novel imidazo-pyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, m, n, and R1to R3 are as described herein: formula (I). Further provided are pharmace

Triazole derivative having HSP90 (Heat Shock Protein) inhibiting activity, as well as preparation method and application of triazole derivative

The invention discloses a triazole derivative having an HSP90 (Heat Shock Protein) inhibiting activity, as well as a preparation method and an application of the triazole derivative. Specifically, the invention relates to the triazole derivative having a structure as shown in a formula (I), a stereisomer of the triazole derivative and a pharmaceutically acceptable salt, wherein the definition of each substituent group in the formula (I) and the definition in a description are the same. The compound with a novel structure has the HSP90 inhibiting activity, can be used to cure cancers, neurodegenerative disorders, inflammation diseases, autoimmune diseases, ischemic brain injuries and the like, and has a broad application prospect.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

The HGF-c-Met signaling axis is an important paracrine mediator of epithelial-mesenchymal cell interactions involving the regulation of multiple cellular activities including cell motility, mitogenesis, morphogenesis, and angiogenesis. Dysregulation of c-Met signaling (e.g., overexpression or increased activation) is associated with the development of a wide range of tumor types; thus, inhibiting the HGF-c-Met pathway is predicted to lead to anti-tumor effects in many cancers. Elaboration of a 2-arylaminopyrimidine scaffold led to a series of potent c-Met inhibitors bearing a C4-2-amino-N-methylbenzamide group. Specifically, a series of C2-benzazepinone analogs demonstrated potent inhibition of c-Met in enzymatic and cellular assays. Kinase selectivity could be tuned by varying the nature of the alkyl group on the benzazepinone nitrogen.

1-Benzazepine-3-Sulfonylamino-2-Pyrroridones as Factor Xa Inhibitors

The invention relates to chemical entities of formula (I): and/or pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds

OXAZOLIDINONE DERIVATES N-SUBSTITUTED BY A TRICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial P is a tricyclic ring system as defined in claiml.

Synthesis of 7-mercapto-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

The synthesis of 7-mercapto-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one - a potential monomer for preparing network polymers - is reported.

Lipoxygenase Inhibitors, III: Synthesis of Tetrahydrobenzazepinone Phenylhydrazones

Tetrahydro-2H-benzazepin-2-ones as starting substances are synthesized by Beckmann rearrangement or Schmidt reaction.The tetrahydrobenzazepinones are transformed into the thiones, thiolactim ethers and phenylhydrazones.The compounds are tested as inhibitors of soja lipoxygenase.