3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate

Base Information

• Chemical Name: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate
• CAS No.: 1259017-54-3
• Molecular Formula: C₃₀H₃₀ClFN₄O₃S₃
• Molecular Weight: 645.243
• Mol file: 1259017-54-3.mol

Synonyms:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate

Chemical Property of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate

There total 8 articles about 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Thiomorpholin (123-90-0) + carbon disulfide (75-15-0,12122-00-8) + N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine (1259017-73-6) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate (1259017-54-3)

Guidance literature:

Thiomorpholin; With potassium phosphate; In N,N-dimethyl-formamide; for 0.25h;

carbon disulfide; In N,N-dimethyl-formamide; for 0.5h;

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline (692059-41-9) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate (1259017-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 3 h / Reflux

2.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With potassium phosphate; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol (574738-93-5) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl thiomorpholine-4-carbodithioate (1259017-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: triethylamine / isopropyl alcohol / 3 h / Reflux

3.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

3.2: 0.5 h

With potassium phosphate; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.04.096

upstream raw materials:

Thiomorpholin

carbon disulfide

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine

6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline

Refernces