20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

Base Information

Chemical Name:20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one
CAS No.:1321919-30-5
Molecular Formula:C₄₂H₄₆N₂O₂S
Molecular Weight:642.905
Hs Code.:

Synonyms:20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

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Chemical Property of 20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

Chemical Property:

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Technology Process of 20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

There total 4 articles about 20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1321919-26-9
17-[2'-hydroxy-4'-oxo-4'-phenyl-3'-(phenylamino)butan-2-yl]androst-4-en-3-one

: 103-72-0
phenyl isothiocyanate

: 1321919-30-5
20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

Guidance literature:: With triethylamine; In ethanol; Reflux;
DOI:10.1016/j.steroids.2011.05.011

Reference yield:

: 1321919-25-8
17-(3'-benzoyl-2'-methyloxiran-2'-yl)androst-4-ene-3-one

: 1321919-30-5
20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux

2: triethylamine / ethanol / Reflux

With triethylamine; In ethanol;
DOI:10.1016/j.steroids.2011.05.011

Reference yield:

: 57-83-0
Progesterone

: 1321919-30-5
20-hydroxy-20-[1',3',4'-triphenyl-2'-thioxo-1',3'-imidazol-5'-yl]pregn-4-ene-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium; tert-butyl alcohol / 30 h / 20 - 70 °C

2: triethylamine / ethanol / Reflux

3: triethylamine / ethanol / Reflux

With potassium; triethylamine; tert-butyl alcohol; In ethanol; 1: Darzens condensation;
DOI:10.1016/j.steroids.2011.05.011