3,8-Dimethylquinoline

Base Information

• Chemical Name: 3,8-Dimethylquinoline
• CAS No.: 20668-29-5
• Molecular Formula: C11H11 N
• Molecular Weight: 157.21
• Hs Code.: 2933499090
• Mol file: 20668-29-5.mol

Synonyms:3,8-Dimethylquinoline

Chemical Property of 3,8-Dimethylquinoline

Chemical Property:

• Melting Point: 51.53°C (estimate)
• Refractive Index: 1.6063
• Boiling Point: 266.88°C (estimate)
• PKA: 5.21±0.28(Predicted)
• PSA: 12.89000
• Density: 1.0510
• LogP: 2.85160

Purity/Quality:

99%min ^*data from raw suppliers

3,8-dimethyl-Quinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,8-Dimethylquinoline

There total 12 articles about 3,8-Dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-methylene-1-(o-tolyl) azetidine → 3,8-dimethylquinoline (20668-29-5)

Guidance literature:

With silver(I) acetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 110 ℃; for 2h; regioselective reaction; Microwave irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01427

Reference yield: 36.0%

2-methyl-1.3-propanediol (2163-42-0) + o-toluidine (95-53-4) → 3,8-dimethylquinoline (20668-29-5)

Guidance literature:

With ruthenium trichloride; tributylphosphine; MgBr₂*Et₂O; In 1,3,5-trimethyl-benzene; for 16h; Inert atmosphere; Reflux;

DOI:10.1039/c0ob00676a

Reference yield:

2-methylpropenal (78-85-3,25120-30-3) + o-toluidine (95-53-4) → 3,8-dimethylquinoline (20668-29-5)

Guidance literature:

With 1-methyl-2-nitrobenzene; sulfuric acid; iron(II) sulfate; at 140 ℃;

upstream raw materials:

3,8-dimethyl-quinoline-2-carboxylic acid

2-methylpropenal

o-toluidine

methallylidene diacetate

Refernces

• 1、 He, Yimiao,Huang, Lilan,Xie, Limei,Liu, Peng,Wei, Qiongmei,Mao, Fangfang,Zhang, Xuehong,Huang, Jun,Chen, Sijing,Huang, Chusheng. "Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents". . p. 10088 - 10101. Retrieved 2019/08/22.
• 2、 Monrad, Rune Nygaard,Madsen, Robert. "Ruthenium-catalysed synthesis of 2- and 3-substituted quinolines from anilines and 1,3-diols". experimental part. p. 610 - 615. Retrieved 2011/02/28.