2163-42-0

Basic information

• Product Name: 2-METHYL-1,3-PROPANEDIOL
• Synonyms: 2163-42-0;2-Methyl-1,3-propanediol (MPO);Methyl propane diol (MP Diol);2-Methyl-1,3-propanediol 99%;1,3-DIHYDROXY-2-METHYLPROPANE;2-METHYL-PROPAN-1,3-DIOL;2-METHYL-1,3-PROPANEDIOL;2-methyl-3-propanediol
• CAS NO: 2163-42-0
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.121
• EINECS: 412-350-5
• Product Categories: application fields are synthetic leather pulp, polyurethane coating, food flexible packaging composite with polyurethane adhesive and so on.;Alcohols;Monomers;Polymer Science
• Mol File: 2163-42-0.mol
• Article Data: 30

Chemical Properties

• Melting Point: −91 °C(lit.)
• Boiling Point: 123-125 °C20 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Density: 3.2 (vs air)
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: n20/D 1.445(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Soluble), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.51±0.10(Predicted)
• BRN: 1731422
• CAS DataBase Reference: 2-METHYL-1,3-PROPANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1,3-PROPANEDIOL(2163-42-0)
• EPA Substance Registry System: 2-METHYL-1,3-PROPANEDIOL(2163-42-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 1
• Hazardous Substances Data: 2163-42-0(Hazardous Substances Data)

Usage

Uses

β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.

InChI:InChI=1/C4H10O2/c1-4(2-5)3-6/h4-6H,2-3H2,1H3

Synthetic route

2-(Hydroxymethyl)allyl alcohol (3513-81-3) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen at 60℃; under 15001.5 Torr;	97%

Diethyl methylmalonate (609-08-5) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	90%
With borane In tetrahydrofuran at -78 - 20℃;	87%
With lithium aluminium tetrahydride In diethyl ether for 3h; Heating;	85%

dimethyl 3-methylglutarate (19013-37-7) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	85%

1,3-diacetoxy-2-methylpropane (55289-53-7) → 2-methyl-1.3-propanediol (2163-42-0) + (2R)-acetic acid 3-hydroxy-2-methyl-propyl ester (119786-13-9)

Conditions	Yield
In water Pseudomonas fluorescens lipase (PFL);	A n/a B 38%

2-methyl-1,3-propanedialdehyde (16002-19-0) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride	35%

formaldehyd (50-00-0) + benzophenone (119-61-9) + diethyl ether (60-29-7) → 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
Irradiation;

formaldehyd (50-00-0) + benzophenone (119-61-9) + diethyl ether (60-29-7) → 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) + 2-methyl-1.3-propanediol (2163-42-0) + hydroxy-2-propanone (116-09-6)

Conditions	Yield
Sonnenlicht.Irradiation;

formaldehyd (50-00-0) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With benzophenone; diethyl ether; water Irradiation.mit UV-Licht;

methyl 3-hydroxy-2-methylpropanoate (64809-29-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

1,3-diacetoxy-2-methylpropane (55289-53-7) + sodium ethanolate (141-52-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With ethanol

diethyl 2-ethoxymethylenemalonate (87-13-8) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With copper chromite; ethanol at 150℃; under 257428 Torr; Hydrogenation;

formaldehyd (50-00-0) + acetaldehyde (75-07-0) → Pentaerythritol (115-77-5) + 2-methyl-1.3-propanediol (2163-42-0) + 2-hydroxymethyl-1,3-propanediol (4704-94-3) + trimethyleneglycol (504-63-2)

Conditions	Yield
With sodium hydroxide; sulfuric acid; hydrogen; 5% activated charcoal-supported ruthenium catalyst 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With sodium hydroxide; sulfuric acid; hydrogen; Ru-carbon 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C 4 h; Yield given. Multistep reaction. Yields of byproduct given;

3-hydroxy-2-methyl-1-propene (513-42-8) → 2-Methyl-1,2-propanediol (558-43-0) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium acetate Product distribution; 1.) THF, 25 deg C, 6 h, 2.) room temp.;	A 0.5 % Chromat. B 99.5 % Chromat.

carbon monoxide (201230-82-2) + allyl alcohol (107-18-6) → propan-1-ol (71-23-8) + Butane-1,4-diol (110-63-4) + 2-methyl-propan-1-ol (78-83-1) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With dirhodium tetraacetate; hydrogen; triethylphosphine In ethanol at 120℃; under 30400 Torr; for 4h; Product distribution; hydrocarbonylation, effect of time, CO:H2 ratio, PEt3:Rh ratio, temperature, and pressure;

(E)-(2R,6R)-6-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-6-methoxy-2-methyl-hex-3-en-1-ol → 2-methyl-1.3-propanediol (2163-42-0) + (R)-3-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-3-methoxy-propan-1-ol

Conditions	Yield
With sodium tetrahydroborate; ozone 1.) CH2Cl2, MeOH, 2.) -78 - 25 deg C; Yield given. Multistep reaction;

(E)-(2R,6S)-6-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-6-methoxy-2-methyl-hex-3-en-1-ol → 2-methyl-1.3-propanediol (2163-42-0) + (S)-3-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-3-methoxy-propan-1-ol

Conditions	Yield
With sodium tetrahydroborate; ozone 1.) CH2Cl2, MeOH, 2.) -78 - 25 deg C; Yield given. Multistep reaction;

2-isopropoxy-4-methyl-[1,2]oxaborolane → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In water at 20℃; for 2h; Oxidation;

ethanol (64-17-5) + diethyl 2-ethoxymethylenemalonate (87-13-8) + copper chromite → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
at 150℃; under 257428 Torr; Hydrogenation;

diethyl 2-ethoxymethylenemalonate (87-13-8) + Raney nickel → 2-methyl-1.3-propanediol (2163-42-0) + Diethyl methylmalonate (609-08-5)

Conditions	Yield
at 125℃; Hydrogenation;

2-methyl-propanediol-(1.3)-diacetate → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogenchloride

methyltrimethylene bromide → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With acetic acid Verseifung das Diacetat mit Baryt;

trimethylaluminum (75-24-1) + oxiranyl-methanol (556-52-5) → 2-methyl-1.3-propanediol (2163-42-0) + 1,2-dihydroxybutane (584-03-2)

Conditions	Yield
Stage #1: trimethylaluminum; oxiranyl-methanol In dichloromethane at 0℃; for 0.166667h; Stage #2: With potassium fluoride; water In dichloromethane at 25℃; for 0.5h;	A 9.8 % Chromat. B 90.2 % Chromat.

2-hydroxytetrahydrofuran (5371-52-8) + 3-hydroxy-2-methylpropanal (38433-80-6) → Butane-1,4-diol (110-63-4) + 2-methyl-1.3-propanediol (2163-42-0)

1,4-dioxane (123-91-1) + raney nickel-iron + methallylacetate + Acetol acetate (592-20-1) + 1,3-diacetoxy-2-methylenepropane (3775-29-9) + 2-(acetoxymethyl)prop-2-en-1-ol (57859-50-4) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen; sodium methylate; acetic acid In methanol; acetic acid methyl ester; water

1,3-diacetoxy-2-methylenepropane (3775-29-9) + rhodium (378784-00-0, 7440-16-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium methylate In methanol

methallylacetate + Acetol acetate (592-20-1) + 1,3-diacetoxy-2-methylenepropane (3775-29-9) + 2-(acetoxymethyl)prop-2-en-1-ol (57859-50-4) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium hydroxide; acetic acid; aluminum nickel In methanol; acetic acid methyl ester; water

1,3-diacetoxy-2-methylenepropane (3775-29-9) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium methylate; aluminum nickel In methanol

carbon monoxide (201230-82-2) + allyl alcohol (107-18-6) → Butane-1,4-diol (110-63-4) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen; acetylacetonatobis(ethylene)rhodium(I); rac-trans-1,2-bis[di(3,5-dimethylphenyl)phosphinomethyl]cyclobutane; triethylphosphine In ethanol at 120℃; under 22502.3 - 30003 Torr; Product distribution / selectivity; Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + acetic anhydride (108-24-7) → 1,3-diacetoxy-2-methylpropane (55289-53-7)

Conditions	Yield
With pyridine Acetylation;	100%
With pyridine In tetrahydrofuran at 20℃; for 48h;	95%
With pyridine
With pyridine Ambient temperature;

2-methyl-1.3-propanediol (2163-42-0) + cyclohexanone (108-94-1) → 3-methyl-1,5-dioxaspiro<5.5>undecane (223421-39-4)

Conditions	Yield
With pyridinium p-toluenesulfonate In benzene for 8.5h; Heating;	100%
With toluene-4-sulfonic acid In benzene Heating;	68%
With pyridine; toluene-4-sulfonic acid In benzene Condensation; Heating;

2-methyl-1.3-propanediol (2163-42-0) + 4-methoxy-benzaldehyde (123-11-5) → trans-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 24h; Heating;	100%
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	76%

2-methyl-1.3-propanediol (2163-42-0) + benzaldehyde (100-52-7) → 5-methyl-2-phenyl-[1,3]dioxane (27942-89-8)

Conditions	Yield
With toluene-4-sulfonic acid In benzene Acetalization;	98%
With toluene-4-sulfonic acid In toluene Heating;

2-methyl-1.3-propanediol (2163-42-0) + p-toluenesulfonyl chloride (98-59-9) → 2-methylpropane-1,3-diyl bis(4-methylbenzenesulfonate) (24330-53-8)

Conditions	Yield
With triethylamine In dichloromethane at 10 - 25℃; for 5h;	97.25%
With triethylamine In dichloromethane at 20℃; for 18h;	93.1%
With triethylamine In dichloromethane at 20℃; for 18h;	93.1%

2-methyl-1.3-propanediol (2163-42-0) + MPDO ketal of ethyl levulinate → C22H38O8

Conditions	Yield
With titanium(IV) isopropylate at 110 - 210℃; Inert atmosphere;	96.9%
Stage #1: 2-methyl-1.3-propanediol; MPDO ketal of ethyl levulinate at 110℃; for 0.75h; Dean-Stark; Inert atmosphere; Stage #2: With titanium(IV) isopropylate at 165 - 210℃; for 4h; Dean-Stark; Inert atmosphere;	96.9%

2-methyl-1.3-propanediol (2163-42-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropan-1-ol (125244-91-9)

Conditions	Yield
With sodium hydride In tetrahydrofuran	96%
With 1H-imidazole at 20℃;	95%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.75h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 20℃; for 1h;	94%

2-methyl-1.3-propanediol (2163-42-0) → diboronic ester + 5,5'-Dimethyl-2,2'-bi-1,3,2-dioxaborinane (230299-25-9)

Conditions	Yield
	A 96% B n/a

2-methyl-1.3-propanediol (2163-42-0) + 1-(mesitylsulfonyl)piperidine-4-carbaldehyde → 1-(mesitylsulfonyl)-4-(5-methyl-1,3-dioxan-2-yl)piperidine

Conditions	Yield
With pyridinium p-toluenesulfonate; magnesium sulfate In toluene for 3.5h; Reflux;	95%

2-methyl-1.3-propanediol (2163-42-0) + p-methoxybenzyl chloride (824-94-2) → (+/-)-3-(4-methoxybenzyl)oxy-2-methyl-1-propanol (374716-64-0)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; mineral oil at 55℃; for 16h;	94%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: p-methoxybenzyl chloride With sodium iodide In tetrahydrofuran at 50℃; for 20h; Further stages.;	71%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride Inert atmosphere; Stage #2: p-methoxybenzyl chloride Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + acetyl chloride (75-36-5) → 1,3-diacetoxy-2-methylpropane (55289-53-7)

Conditions	Yield
In chloform at 20℃; for 24h;	94%
In chloroform at 20℃; for 24h;	94%

2-methyl-1.3-propanediol (2163-42-0) + O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → 3-(4-methoxybenzyloxy)-2-methylpropan-1-ol

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol In dichloromethane at 20℃; for 0.5h; Molecular sieve; Inert atmosphere; Stage #2: O-(4-methoxybenzyl)-trichloroacetimidate With pyridinium p-toluenesulfonate at 20℃; for 25.5h; Inert atmosphere;	94%

2-methyl-1.3-propanediol (2163-42-0) + 2-Chloro-2-oxo-1,3,2-dioxaphospholane (6609-64-9) → C8H16O8P2

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Chloro-2-oxo-1,3,2-dioxaphospholane In dichloromethane at 0 - 20℃; for 12h;	94%

2-methyl-1.3-propanediol (2163-42-0) + 2-chloro-1,3,2-dioxaphospholan (822-39-9) → C8H16O6P2

Conditions	Yield
In dichloromethane at 0 - 20℃; for 12h;	94%

2-methyl-1.3-propanediol (2163-42-0) + acetic anhydride (108-24-7) → 2-(acetoxymethyl)propan-1-ol (55378-40-0)

Conditions	Yield
With cerium(III) chloride In tetrahydrofuran	93%
With pyridine for 4h; Ambient temperature;	78%
Stage #1: 2-methyl-1.3-propanediol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran; hexane at -78 - 20℃; for 14h; Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + benzaldehyde dimethyl acetal (1125-88-8) → 5-methyl-2-phenyl-[1,3]dioxane (27942-89-8)

Conditions	Yield
With graphene In neat (no solvent) at 100℃; for 10h; Sealed tube;	92%

2-methyl-1.3-propanediol (2163-42-0) → (2R)-3-hydroxy-2-methylpropanoic acid (1910-47-0)

Conditions	Yield
With Acetobacter aceti MIM 2000/28; air In water at 28℃; for 0.166667h; Flow reactor; Enzymatic reaction; regioselective reaction;	91%
With acetobacter aceti culture medium containing glucose, yeast extract, agar, glycerol and distilled water for 72h; Microbiological reaction; enantioselective reaction;	89%
With air; Acetobacter pasteurianus DSM 8937 at 32℃; pH=7.2; Product distribution; Further Variations:; pH-values; Temperatures;

2-methyl-1.3-propanediol (2163-42-0) + Chlorodiisopropylphosphane (40244-90-4) → 1,3-bis(di-iso-propylphosphanyloxy)-2-methylpropane (1350979-50-8)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere; Stage #2: Chlorodiisopropylphosphane In tetrahydrofuran; hexane at 0℃; Inert atmosphere;	91%

2-methyl-1.3-propanediol (2163-42-0) + acetyl chloride (75-36-5) → 1-acetoxy-3-chloro-2-methyl-propane (2159-71-9, 82560-89-2)

Conditions	Yield
	90%

N-hydroxyphthalimide (524-38-9) + 2-methyl-1.3-propanediol (2163-42-0) → 2,2'-[(2-methylpropane-1,3-diyl)bis(oxy)]bis(1H-isoindole-1,3(2H)-dione) (1034431-60-1)

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	90%

2-methyl-1.3-propanediol (2163-42-0) + vinyl benzoate (769-78-8) → (S)-3-hydroxy-2-methylpropyl benzoate (141978-58-7)

Conditions	Yield
With diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol) In toluene at -20℃; for 24h; Inert atmosphere; optical yield given as %ee;	88%

cycloxexanone dimethyl ketal (933-40-4) + 2-methyl-1.3-propanediol (2163-42-0) → 3-methyl-1,5-dioxaspiro<5.5>undecane (223421-39-4)

Conditions	Yield
With graphene In neat (no solvent) at 100℃; for 10h; Sealed tube;	86%

2-methyl-1.3-propanediol (2163-42-0) + 4-tert-Butylbenzaldehyde (939-97-9) → trans-2-(4-(tert-butyl)phenyl)-5-methyl-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	86%

2-methyl-1.3-propanediol (2163-42-0) + 2',4',6'-trimethyl-[1,1'-biphenyl]-4-carbaldehyde (106359-72-2) → trans-5-methyl-2-(2’,4’,6’-trimethyl-[1,1’-biphenyl]-4-yl)-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	85%

2-methyl-1.3-propanediol (2163-42-0) + dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) → 3-(dibenzyl)phosphoryloxy-2-methyl-1-propanol

Conditions	Yield
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere; chemoselective reaction;	84%
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;	84%
With tetrahexylammonium iodide; silver(l) oxide In dichloromethane at 20℃; for 20h;	74%
With titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 16h; Inert atmosphere; enantioselective reaction;	54%

2-methyl-1.3-propanediol (2163-42-0) + di(tert-butyl)chlorophosphine (13716-10-4) → 1,3-bis(di-tert-butylphosphanyloxy)-2-methylpropane (1350979-33-7)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With potassium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: di(tert-butyl)chlorophosphine In tetrahydrofuran for 20h; Inert atmosphere;	84%

2-methyl-1.3-propanediol (2163-42-0) + pivaloyl chloride (3282-30-2) → (+/-)-2-methyl-3-trimethylacetoxy-1-propanol (914802-22-5)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	83%

Upstream product

• 55289-53-7 1,3-diacetoxy-2-methylpropane 
• 141-52-6 sodium ethanolate 
• 16002-19-0 2-methyl-1,3-propanedialdehyde 
• 201230-82-2 carbon monoxide 
• 107-18-6 allyl alcohol 
• 64-17-5 ethanol 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 67-56-1 methanol 
• 504-63-2 trimethyleneglycol 
• 3513-81-3 2-(Hydroxymethyl)allyl alcohol 
• 3775-29-9 1,3-diacetoxy-2-methylenepropane 
• 592-20-1 Acetol acetate 
• 57859-50-4 2-(acetoxymethyl)prop-2-en-1-ol 
• 378784-00-0 rhodium 

Downstream Products

• 34288-24-9 5-methyl-2-phenyl-1,3,2-dioxaborinane 
• 119786-13-9 (2R)-acetic acid 3-hydroxy-2-methyl-propyl ester 
• 75-07-0 acetaldehyde 
• 24330-53-8 2-methylpropane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 28148-04-1 1,3-dibromo-2-methylpropane 
• 1910-47-0 (R)-3-hydroxy-2-methyl propionic acid 
• 26543-05-5 (S)-(+)-3-hydroxy-2-methyl-propanoic acid 
• 73757-46-7 5-Methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 73757-49-0 5-Methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 27942-89-8 5-methyl-2-phenyl-[1,3]dioxane 
• 141978-59-8 (R)-1-O-benzoyl-2-methylpropane-1,3-diol 
• 141978-58-7 (S)-3-hydroxy-2-methylpropyl benzoate 
• 123284-89-9 (+/-)-2-methyl-3-[(tert-butyldiphenylsilyl)oxy]propanal 

Relevant articles and documents

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Method for preparing 2-methyl-1, 3-propylene glycol from isobutene

The invention discloses a method for preparing 2-methyl-1, 3-propylene glycol from isobutene. The method comprises the following steps: mixing isobutene with acetic acid and oxygen, and carrying out an oxyacetylation reaction under the action of a supported palladium-molybdenum catalyst to obtain 2-methylene propane-1, 3-diacetoxy, namely a compound (C); carrying out transesterification on the compound (C) under the action of a basic catalyst to obtain 2-methylene-1, 3-propylene glycol, namely a compound (D); and carrying out hydrogenation reaction on the compound (D) to obtain the 2-methyl-1,3-propylene glycol. According to the method, the 2-methyl-1, 3-propylene glycol can be generated with high selectivity, and the whole process is high in atom utilization rate, environmentally friendly and suitable for large-scale industrial application.

Direct hydrocarbonylation process

A direct hydrocarbonylation process for the production of 1,4-butanediol is described. The process comprises reacting allyl alcohol with carbon monoxide and hydrogen in an alcohol solvent in the presence of a catalyst system comprising a rhodium complex, a trialkyl phosphine, and a diphosphine. The process gives a high yield of 1,4-butanediol in a one-step reaction.