2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

Base Information

Chemical Name:2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol
CAS No.:1369394-45-5
Molecular Formula:C₁₈H₁₂Cl₂F₄N₂O
Molecular Weight:419.206
Hs Code.:

Synonyms:2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

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Chemical Property of 2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

Chemical Property:

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Technology Process of 2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

There total 8 articles about 2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369399-07-4
[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

: 917-54-4
methyllithium

: 1369394-45-5
2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

Guidance literature:: [2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone; methyllithium; In tetrahydrofuran; diethyl ether; at -28 - 0 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 1369399-02-9
ethyl 1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazole-5-carboxylate

: 1369394-45-5
2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1.08 h / -40 - -15 °C

1.2: 0.5 h / -17 - 20 °C

2.1: water; sodium hydroxide / methanol / 12 h / 40 °C

2.2: pH 2 / Cooling with ice

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.92 h

4.1: sodium carbonate / dichloromethane / 12 h

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.67 h / -40 - -2.5 °C

5.2: 12 h / -2.5 - 20 °C

6.1: tetrahydrofuran; diethyl ether / 0.5 h / -28 - 0 °C

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; oxalyl dichloride; water; isopropylmagnesium chloride; sodium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: 1369399-03-0
C₁₀H₈ClF₂NO₂

: 1369394-45-5
2-chloro-1-(2-chloro-4,6-difluorophenyl)-a-(2,4-difluorophenyl)-α,4-dimethyl-1H-imidazole-5-methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ethanol / 2 h / Reflux

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1.08 h / -40 - -15 °C

2.2: 0.5 h / -17 - 20 °C

3.1: water; sodium hydroxide / methanol / 12 h / 40 °C

3.2: pH 2 / Cooling with ice

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.92 h

5.1: sodium carbonate / dichloromethane / 12 h

6.1: isopropylmagnesium chloride / tetrahydrofuran / 1.67 h / -40 - -2.5 °C

6.2: 12 h / -2.5 - 20 °C

7.1: tetrahydrofuran; diethyl ether / 0.5 h / -28 - 0 °C

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; oxalyl dichloride; water; isopropylmagnesium chloride; sodium carbonate; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;