[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

Base Information

Chemical Name:[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone
CAS No.:1369399-07-4
Molecular Formula:C₁₇H₈Cl₂F₄N₂O
Molecular Weight:403.163
Hs Code.:

Synonyms:[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

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Chemical Property of [2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

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Technology Process of [2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

There total 7 articles about [2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 1369399-06-3
2-chloro-1-(2-chloro-4,6-difluorophenyl)-N-methoxy-N,4-dimethyl-1H-imidazole-5-carboxamide

: 1369399-07-4
[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

Guidance literature:: 2,4-difluorobromobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -40 - -2.5 ℃; for 1.66667h;

2-chloro-1-(2-chloro-4,6-difluorophenyl)-N-methoxy-N,4-dimethyl-1H-imidazole-5-carboxamide; In tetrahydrofuran; at -2.5 - 20 ℃; for 12h;

Reference yield:

: 1369399-03-0
C₁₀H₈ClF₂NO₂

: 1369399-07-4
[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ethanol / 2 h / Reflux

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1.08 h / -40 - -15 °C

2.2: 0.5 h / -17 - 20 °C

3.1: water; sodium hydroxide / methanol / 12 h / 40 °C

3.2: pH 2 / Cooling with ice

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.92 h

5.1: sodium carbonate / dichloromethane / 12 h

6.1: isopropylmagnesium chloride / tetrahydrofuran / 1.67 h / -40 - -2.5 °C

6.2: 12 h / -2.5 - 20 °C

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; oxalyl dichloride; water; isopropylmagnesium chloride; sodium carbonate; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1369399-05-2
2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazole-5-carboxylic acid

: 1369399-07-4
[2-chloro-1-(2-chloro-4,6-difluorophenyl)-4-methyl-1H-imidazol-5-yl]-(2,4-difluorophenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.92 h

2.1: sodium carbonate / dichloromethane / 12 h

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1.67 h / -40 - -2.5 °C

3.2: 12 h / -2.5 - 20 °C

With oxalyl dichloride; isopropylmagnesium chloride; sodium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;