5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt

Base Information

• Chemical Name: 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt
• CAS No.: 131980-53-5
• Molecular Formula: C₁₂H₁₂ClN₃O₂S*ClH
• Molecular Weight: 334.226
• Mol file: 131980-53-5.mol

Synonyms:5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt

Chemical Property of 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt

There total 2 articles about 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl 5-(4-chlorophenyl)-2-formylimino-1,3,4-thiadiazole-3(2H)-butanoate (131980-51-3) → 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt (131980-53-5)

Guidance literature:

With hydrogenchloride; acetic acid; at 100 ℃; for 16h;

DOI:10.1071/CH9901767

Reference yield:

2-amino-5-(4-chlorophenyl)-1,3,4-thiadiazole (28004-62-8) → 5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazole-3(2H)-butanoic acid, hydrochloride salt (131980-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / 16 h / 80 °C

2: 67 percent / concd.HCl, glacial acetic acid / 16 h / 100 °C

With hydrogenchloride; acetic acid;

DOI:10.1071/CH9901767

upstream raw materials:

ethyl 5-(4-chlorophenyl)-2-formylimino-1,3,4-thiadiazole-3(2H)-butanoate

2-amino-5-(4-chlorophenyl)-1,3,4-thiadiazole