28004-62-8

Basic information

• Product Name: 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4-
• Synonyms: 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4-;5-(4-Chlorophenyl)-[1,3,4]thiadiazol-2-ylamine;Albb-006411;5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-amine, 1-(5-Amino-1,3,4-thiadiazol-2-yl)-4-chlorobenzene;2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole 97%;1,3,4-Oxadiazole, 2-amino-5-(4-chlorophenyl)-
• CAS NO: 28004-62-8
• Molecular Formula: C₈H₆ClN₃S
• Molecular Weight: 211.675
• Product Categories: Amines;Oxadiazoles & Thiadiazoles;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiadiazoles;ThiadiazolesHeterocyclic Building Blocks
• Mol File: 28004-62-8.mol
• Article Data: 93

Chemical Properties

• Melting Point: 229-233 °C(lit.)
• Boiling Point: 383.9 °C at 760 mmHg
• Flash Point: 186 °C
• Appearance: /
• Density: 1.461 g/cm³
• Vapor Pressure: 4.26E-06mmHg at 25°C
• Refractive Index: 1.676
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.33±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4-(28004-62-8)
• EPA Substance Registry System: 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4-(28004-62-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 28004-62-8(Hazardous Substances Data)

Usage

Description

2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole, with the molecular formula C8H6ClN3S, is a heterocyclic organic compound characterized by the presence of a thiadiazole ring and an amino group. 2-AMINO-5-(4-CHLOROPHENYL)-1 3 4exhibits potential pharmaceutical applications, particularly in antimicrobial and antifungal properties, and may contribute to the development of new drugs for various medical conditions. Furthermore, it serves as a building block in the synthesis of other chemical compounds and has potential applications in agricultural and industrial processes.

Uses

Used in Pharmaceutical Applications:
2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole is used as a pharmaceutical agent for its antimicrobial and antifungal properties, offering potential in the development of new drugs to combat various infections and diseases.
Used in Drug Development:
2-AMINO-5-(4-CHLOROPHENYL)-1 3 4is utilized in the development of new drugs for various medical conditions, leveraging its potential pharmaceutical applications and chemical properties.
Used in Chemical Synthesis:
2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole serves as a building block in the synthesis of other chemical compounds, contributing to the creation of novel molecules with diverse applications.
Used in Agricultural Applications:
2-AMINO-5-(4-CHLOROPHENYL)-1 3 4may have applications in agriculture, potentially serving as a component in the development of new agrochemicals or contributing to the improvement of existing products.
Used in Industrial Processes:
2-Amino-5-(4-chlorophenyl)-1,3,4-thiadiazole may also find use in various industrial processes, where its unique chemical properties can be harnessed for specific applications or improvements in product development.

InChI:InChI=1/C8H6ClN3S/c9-6-3-1-5(2-4-6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)

Upstream product

• 64310-32-3 1-(4-chlorobenzoyl)thiosemicarbazide 
• 104-88-1 4-chlorobenzaldehyde 
• 79-19-6 thiosemicarbazide 
• 74-11-3 para-chlorobenzoic acid 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 333-20-0 potassium thioacyanate 
• 20038-92-0 C-(4-Chlor-phenylazo)-thioformamid 
• 4346-94-5 thiosemicarbazide hydrochloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 5706-80-9 4-chlorobenzaldehyde thiosemicarbazone 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 64310-32-3 C₈H₈ClN₃OS 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 70038-94-7 N-[5-(4-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-acetamidine 
• 201343-25-1 [5-(4-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-[1,3]dithiolan-2-ylidene-amine 
• 935853-31-9 C₁₇H₁₁ClN₄SO 
• 1236182-60-7 9-(4-methoxy)-5-(4'-chlorophenyl)-3H,13aH-quinolino-[3,2-f][1,2,4]triazolo[4,3-b][1,2,4]triazepine 
• 1303531-64-7 C₁₈H₂₅ClN₄OS 
• 1303531-65-8 C₁₈H₂₅ClN₄OS 
• 1303531-66-9 C₁₄H₁₅ClN₄O₂S 
• 57709-58-7 2-bromo-5-(4-chlorophenyl)-1,3,4-thiadiazole 

Relevant articles and documents

A new dual-function fluorescent probe of Fe3+for bioimaging and?probe-Fe3+complex for selective detection of CN?

A rhodamine-based probe for Fe3+was prepared and confirmed by X-ray crystallography. The probe exhibited highly selective and sensitive recognition toward Fe3+with distinct color change. Interestingly, the probe-Fe3+comple

Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi

A series of new 1,3,4-thiadiazole Emodin amide derivatives were synthesized through the connection of 5-substituted-1,3,4-thiadiazole-2-amine and Emodin carboxylic acids which were obtained by a two-step procedure starting from Emodin. Vibrio harveyi inhibition activities of the newly prepared compounds were evaluated. Results revealed that all compounds showed different degrees of inhibition on V. harveyi. Among them, compound 7a showed the best V. harveyi inhibition effect and the minimum inhibitory concentration (MIC) was 0.0625 mg/mL.

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Aryl or heteroaryl substituted thiadiazole compound and antibacterial application thereof

The invention belongs to the technical field of medicines, and particularly relates to an aryl or heteroaryl substituted thiadiazole compound, a preparation method and application thereof as an antibacterial drug. The compound is represented by formula (1