1,3-Piperidinedicarboxylic acid, 3-(iodoMethyl)-, 1-(1,1-diMethylethyl) 3-ethyl ester

Base Information

Chemical Name:1,3-Piperidinedicarboxylic acid, 3-(iodoMethyl)-, 1-(1,1-diMethylethyl) 3-ethyl ester
CAS No.:948589-00-2
Molecular Formula:C₁₄H₂₄INO₄
Molecular Weight:397.253
Hs Code.:
Mol file:948589-00-2.mol

Synonyms:1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Piperidinedicarboxylic acid, 3-(iodoMethyl)-, 1-(1,1-diMethylethyl) 3-ethyl ester

Chemical Property:

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Technology Process of 1,3-Piperidinedicarboxylic acid, 3-(iodoMethyl)-, 1-(1,1-diMethylethyl) 3-ethyl ester

There total 3 articles about 1,3-Piperidinedicarboxylic acid, 3-(iodoMethyl)-, 1-(1,1-diMethylethyl) 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 75-11-6
diiodomethane

: 148672-74-6,130250-54-3
ethyl N-(t-butyloxycarbonyl)nipecotate

: 948589-00-2
1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2011.04.016

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 948589-00-2
1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / tetrahydrofuran / 2 h / 20 °C

2.1: LDA / tetrahydrofuran / 3 h / -78 °C

2.2: 35 percent / tetrahydrofuran / 48 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.05.022

Reference yield:

: 71962-74-8
Ethyl nipecotate

: 948589-00-2
1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / tetrahydrofuran / 2 h / 20 °C

2.1: LDA / tetrahydrofuran / 3 h / -78 °C

2.2: 35 percent / tetrahydrofuran / 48 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.05.022