1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

Base Information

Chemical Name:1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate
CAS No.:948589-03-5
Molecular Formula:C₂₄H₃₃NO₇S
Molecular Weight:479.595
Hs Code.:

Synonyms:1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

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Technology Process of 1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

There total 7 articles about 1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 948589-02-4
C₂₀H₂₉NO₇S

: 3355-28-0
1-Bromo-2-butyne

: 948589-03-5
1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2007.05.022

Reference yield: 76.0%

: 948589-00-2
1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

: 287202-47-5
4-but-2-ynyloxy-benzenesulfonyl fluoride

: 948589-03-5
1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

Guidance literature:: With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-but-2-ynyloxy-benzenesulfonyl fluoride; In tetrahydrofuran; hexane; at 20 ℃; for 4h;

Reference yield:

: 948589-00-2
1-tert-butyl 3-ethyl 3-(iodomethyl)piperidine-1,3-dicarboxylate

: 948589-03-5
1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 3 h / 20 °C

2: mCPBA / CH₂Cl₂ / 3 h / 20 °C

3: 86 percent / Cs₂CO₃ / dimethylformamide / 1 h / 20 °C

With potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.05.022