(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate
CAS No.:1365884-63-4
Molecular Formula:C₂₁H₃₂ClN₃O₄
Molecular Weight:425.956
Hs Code.:

Synonyms:(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

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Chemical Property of (R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

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Technology Process of (R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

There total 3 articles about (R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094360-61-8
6-chloro-N₁-(3-methoxypropyl)benzene-1,2-diamine

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1365884-63-4
(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 2106-49-2
1-chloro-2-fluoro-3-nitrobenzene

: 1365884-63-4
(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: zinc; acetic acid / methanol / 16 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1248906-80-0
2-chloro-N-(3-methoxypropyl)-6-nitroaniline

: 1365884-63-4
(R)-tert-Butyl 3-(3-chloro-2-(3-methoxypropylamino)phen ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / methanol / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In methanol; N,N-dimethyl-formamide;