(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

Base Information

Chemical Name:(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone
CAS No.:110575-89-8
Molecular Formula:C₂₁H₂₆N₂O₄
Molecular Weight:370.448
Hs Code.:

Synonyms:(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

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Chemical Property of (2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

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Technology Process of (2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

There total 7 articles about (2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 61535-24-8
2-amino-3-(benzyloxy)benzoic acid

: 110575-88-7
L-prolinal dimethyl acetal hydrochloride

: 110575-89-8
(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

Guidance literature:: With diethyl cyanophosphonate; 4 A molecular sieve; triethylamine; In tetrahydrofuran; 0 gradC for 1 h. then room temp. for 40 min.;
DOI:10.1016/S0040-4039(00)85411-8

Reference yield:

: 71461-30-8
(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester

: 110575-89-8
(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: ceric trichloride / methanol / room temp. for 0.5 h. then 50 gradC for 21 h.

2: H₂ / Pd/C

3: 77 percent / diethyl phosphorocyanidate, triethylamine, molecular sieves 4A / tetrahydrofuran / 0 gradC for 1 h. then room temp. for 40 min.

With cerium(III) chloride; diethyl cyanophosphonate; 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)85411-8

Reference yield:

: 110562-20-4
Cbz-Pro-L-prolinal dimethyl acetal

: 110575-89-8
(2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: 77 percent / diethyl phosphorocyanidate, triethylamine, molecular sieves 4A / tetrahydrofuran / 0 gradC for 1 h. then room temp. for 40 min.

With diethyl cyanophosphonate; 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)85411-8