(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Base Information

Chemical Name:(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid
CAS No.:1265322-53-9
Molecular Formula:C₂₅H₂₄N₄O₄S
Molecular Weight:476.556
Hs Code.:

Synonyms:(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

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Chemical Property of (3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

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Technology Process of (3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

There total 9 articles about (3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₈N₄O₄S

: 1265322-53-9
(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 50 ℃;

Reference yield:

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1265322-53-9
(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene

2.1: sodium tetrahydroborate / toluene; methanol / 1 h

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 85 °C

4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

4.3: 80 °C

5.1: hydrogenchloride; water / acetonitrile / 50 °C

With hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1265322-53-9
(3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene

2.1: sodium tetrahydroborate / toluene; methanol / 1 h

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 85 °C

4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

4.3: 80 °C

5.1: hydrogenchloride; water / acetonitrile / 50 °C

With hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;