methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate

Base Information

• Chemical Name: methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate
• CAS No.: 1103893-96-4
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 1103893-96-4.mol

Synonyms:methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate

Chemical Property of methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate

There total 2 articles about methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methoxy-aniline (104-94-9) + methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate (1103893-96-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; Reflux;

DOI:10.1002/chem.200801582

Reference yield:

cyclopentanone (120-92-3) → methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate (1103893-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / toluene / Reflux

2: toluene-4-sulfonic acid / methanol / Reflux

With sodium hydride; toluene-4-sulfonic acid; In methanol; toluene;

DOI:10.1002/chem.200801582

Reference yield: 90.0%

methyl 2-((4-methoxyphenyl)amino)cyclopent-1-ene-1-carboxylate (1103893-96-4) → methyl 2-(4-methoxyphenylamino)cyclopentanecarboxylate + methyl 2-(4-methoxyphenylamino)cyclopentanecarboxylate

Guidance literature:

With (S)-(2-(bis(3,3-dimethylphenyl)(hydroxy)methyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone; trichlorosilane; In chloroform; at -30 ℃; for 48h; optical yield given as %ee; diastereoselective reaction;

DOI:10.1002/chem.200801582

upstream raw materials:

4-methoxy-aniline

methyl 2-oxocyclopentane-1-carboxylate

cyclopentanone

Downstream raw materials:

methyl 2-(4-methoxyphenylamino)cyclopentanecarboxylate