5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Chemical Name:5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
CAS No.:1607023-49-3
Molecular Formula:C₁₈H₁₃ClF₃N₅O₂
Molecular Weight:423.782
Hs Code.:

Synonyms:5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Chemical Property of 5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

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Technology Process of 5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

There total 10 articles about 5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1607024-26-9
1-methyl-1H,1'H-3,4'-bipyrazol-5'-amine

: 1607024-34-9
ethyl 3-[4-chloro-3-(2,2,2-trifluoroethoxy)phenyl]-3-oxopropanoate

: 1607023-49-3
5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: With toluene-4-sulfonic acid; In butan-1-ol; for 2h; Reflux;

Reference yield:

: 17827-61-1
methyl ester of 1-methylpyrazole-3-carboxylic acid

: 1607023-49-3
5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 20 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

3: acetonitrile; water / 24 h / 50 °C

4: toluene / 3 h / 85 °C

5: acetic acid; hydrazine hydrate / 4 h / 90 °C

6: toluene-4-sulfonic acid / butan-1-ol / 2 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 84547-62-6
(1-methyl-1H-pyrazol-3-yl)methanol

: 1607023-49-3
5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

2: acetonitrile; water / 24 h / 50 °C

3: toluene / 3 h / 85 °C

4: acetic acid; hydrazine hydrate / 4 h / 90 °C

5: toluene-4-sulfonic acid / butan-1-ol / 2 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In dichloromethane; water; toluene; acetonitrile; butan-1-ol;