Technology Process of MeO-Oxazole-Thiazole-Pro-D-Phe-NHBoc
There total 5 articles about MeO-Oxazole-Thiazole-Pro-D-Phe-NHBoc which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo3017499
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid; methoxybenzene / dichloromethane
2: N-ethyl-N,N-diisopropylamine; HATU; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/ol401749p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethylamino-sulfur trifluoride / -78 °C
1.3: -48 - 20 °C
2.1: formic acid / 2 h / Reflux
3.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
3.3: 0 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid; methoxybenzene / dichloromethane
5.1: N-ethyl-N,N-diisopropylamine; HATU; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
formic acid; diethylamino-sulfur trifluoride; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ol401749p
