5-Thiazolecarboxylicacid,2-amino-4-(hydroxymethyl)-,ethylester(7CI,8CI,9CI)

Base Information

• Chemical Name: 5-Thiazolecarboxylicacid,2-amino-4-(hydroxymethyl)-,ethylester(7CI,8CI,9CI)
• CAS No.: 25039-77-4
• Molecular Formula: C₇H₁₀N₂O₃S
• Molecular Weight: 202.234
• Mol file: 25039-77-4.mol

Synonyms:Ethyl2-amino-4-(hydroxymethyl)-1,3-thiazole-5-carboxylate

Chemical Property of 5-Thiazolecarboxylicacid,2-amino-4-(hydroxymethyl)-,ethylester(7CI,8CI,9CI)

Chemical Property:

• Melting Point: 183-187 °C(Solv: ethanol (64-17-5))
• Boiling Point: 425.6±35.0 °C(Predicted)
• PKA: 12.60±0.10(Predicted)
• PSA: 113.68000
• Density: 1.417±0.06 g/cm3(Predicted)
• LogP: 0.97550

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-amino-4-(hydroxymethyl)thiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarboxylicacid,2-amino-4-(hydroxymethyl)-,ethylester(7CI,8CI,9CI)

There total 7 articles about 5-Thiazolecarboxylicacid,2-amino-4-(hydroxymethyl)-,ethylester(7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-chloro-(3H,5H)-furan-2,4-dione (4971-55-5) + ethanol (64-17-5) + thiourea (17356-08-0) → ethyl 2-amino-4-(hydroxymethyl)-thiazole-5-carboxylate (25039-77-4)

Guidance literature:

for 4h; Reflux;

Reference yield: 70.9%

tetrahydrofuran-2,4-dione (4971-56-6) + ethanol (64-17-5) + thiourea (17356-08-0) → ethyl 2-amino-4-(hydroxymethyl)-thiazole-5-carboxylate (25039-77-4)

Guidance literature:

at 80 ℃; for 5h;

Reference yield: 47.0%

ethyl 2-amino-4-[(benzyloxy)methyl]-1,3-thiazole-5-carboxylate (1093115-36-6) → ethyl 2-amino-4-(hydroxymethyl)-thiazole-5-carboxylate (25039-77-4)

Guidance literature:

With aluminum (III) chloride; In methoxybenzene; at 20 ℃; for 3h;

upstream raw materials:

2-amino-4,5-bis(ethoxycarbonyl)thiazole

ethanol

2-(4-hydroxy-2-oxo-2,5-dihydro-furan-3-yl)-isothiourea; hydrobromide

3-chloro-(3H,5H)-furan-2,4-dione

Downstream raw materials:

2-chloro-5-(ethoxy carbonyl)-1,3-thiazole-4-carboxylic acid

ethyl 2-amino-4-cyano-1,3-thiazole-5-carboxylate