(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride

Base Information

• Chemical Name: (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride
• CAS No.: 115860-78-1
• Molecular Formula: C₁₅H₂₁N₃O₄*ClH
• Molecular Weight: 343.81
• Mol file: 115860-78-1.mol

Synonyms:(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride

Chemical Property of (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride

There total 5 articles about (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methoxy-5-nitrobenzoyl chloride (90763-46-5) + (S)-2-(Aminomethyl)-1-ethylpyrrolidine (22795-99-9) → (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride (115860-78-1)

Guidance literature:

In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jm00118a031

Reference yield:

2-methoxybenzoic acid methyl ester (606-45-1) → (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride (115860-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 18 percent / 10percent HNO₃ / H₂SO₄ / 1 h / 5 °C

2: 95 percent / 2 N NaOH / methanol / 2 h / Heating

3: 97 percent / SOCl₂ / toluene; dimethylformamide / 2 h / 75 °C

4: 72 percent / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; nitric acid; In methanol; dichloromethane; sulfuric acid; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00118a031

Reference yield:

methyl 2-methoxy-5-nitrobenzoate (34841-11-7) → (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-nitrobenzamide hydrochloride (115860-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / 2 N NaOH / methanol / 2 h / Heating

2: 97 percent / SOCl₂ / toluene; dimethylformamide / 2 h / 75 °C

3: 72 percent / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00118a031

upstream raw materials:

2-methoxy-5-nitrobenzoyl chloride

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

2-methoxybenzoic acid methyl ester

methyl 2-methoxy-5-nitrobenzoate

Downstream raw materials:

(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-<3,3-(3-methyl-3-aza-1,5-pentanediyl)triazeno>benzamide

(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-<3,3-(1,5-pentanediyl)triazeno>benzamide

(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-<3,3-(1,4-butanediyl)triazeno>benzamide

(S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-5-amino-2-methoxybenzamide