Technology Process of 2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide
There total 12 articles about 2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 10 - 20 ℃;
for 16h;
DOI:10.1038/ja.2017.116
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine; pivaloyl chloride
2: trifluoroacetic acid
With
pivaloyl chloride; triethylamine; trifluoroacetic acid;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap / dichloromethane / 1 h / 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C
3.1: potassium carbonate / methanol / 1 h / 20 °C
3.2: 3 h / 90 - 100 °C
4.1: triethylamine / dichloromethane / 0.5 h / 0 °C
4.2: 1 h / 0 °C
5.1: trifluoroacetic acid / dichloromethane / 16 h / 10 - 20 °C
With
dmap; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1038/ja.2017.116
