tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate

Base Information

• Chemical Name: tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate
• CAS No.: 1609644-58-7
• Molecular Formula: C₂₂H₂₈N₂O₄
• Molecular Weight: 384.475
• Mol file: 1609644-58-7.mol

Synonyms:tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate

Chemical Property of tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate

There total 13 articles about tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

BOC-glycine (4530-20-5) + (1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol (1081548-91-5) → tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate (1609644-58-7)

Guidance literature:

BOC-glycine; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

(1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol; With pivaloyl chloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1038/ja.2017.116

Reference yield:

(1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol (1081548-91-5) + N-Boc-glycine-pivalic acid mixed anhydride (161203-15-2) → tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate (1609644-58-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.53333h; Inert atmosphere;

DOI:10.1002/anie.201400928

Reference yield:

BOC-glycine (4530-20-5) → tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate (1609644-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.58 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1.53 h / 0 °C / Inert atmosphere

With triethylamine; In dichloromethane;

DOI:10.1002/anie.201400928

upstream raw materials:

BOC-glycine

(1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol

N-Boc-glycine-pivalic acid mixed anhydride

(1R,2R)-2-amino-1,2-diphenylethane-1-ol

Downstream raw materials:

C₂₄H₂₆N₂O₃

C₂₄H₂₅N₃O₅

C₂₅H₂₈N₂O₅S

C₃₁H₃₁ClN₂O₄