<2R(R),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

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Chemical Name:<2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate
CAS No.:124654-47-3
Molecular Formula:C₂₁H₂₂N₂O₇
Molecular Weight:414.415
Hs Code.:

Synonyms:<2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

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Chemical Property of <2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

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Technology Process of <2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

There total 8 articles about <2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (S)-2-((2S,6S)-6-Phenyl-tetrahydro-pyran-2-yl)-propan-1-ol

: 99-33-2
3,5-dinitrobenoyl chloride

: 124654-47-3
<2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81323-5

Reference yield:

: 124654-51-9
2-(benzenesulphonyl)tetrahydro-6-phenyl-2H-pyran

: 124654-47-3
<2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / AlCl₃ / CH₂Cl₂ / 1.) -78 -> -35 deg C, 1 h; 2.) -35 deg C, 1-5 h

2: 1.) LiAlH₄, 2.) Et₃N, DMAP / 1.) ether, 2.) CH₂Cl₂

With dmap; lithium aluminium tetrahydride; aluminium trichloride; triethylamine; In dichloromethane;

Reference yield:

: 4454-05-1
2-methoxy-3,4-dihydro-2H-pyran

: 124654-47-3
<2R*(R*),6R*>-2-<2-(tetrahydro-6-phenyl-2H-pyran-2-yl)propyl> 3,5-dinitrobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) Mg, ZnBr₂, / 1.) THF, RT; 30 min, 2.) THF, RT;

3: 83 percent / CaCl₂ / CH₂Cl₂ / 26 h / Ambient temperature

4: 1.) AlCl₃, / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, -35 deg C,

5: LiAlH₄ / diethyl ether / 1 h / Ambient temperature

6: 84 percent / Et₃N, DMAP, / CH₂Cl₂ / 20 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; aluminium trichloride; magnesium; triethylamine; calcium chloride; zinc dibromide; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)81323-5