6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine

Base Information

• Chemical Name: 6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine
• CAS No.: 1609009-27-9
• Molecular Formula: C₁₁H₁₀Cl₂N₄
• Molecular Weight: 269.133
• Mol file: 1609009-27-9.mol

Synonyms:6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine

Chemical Property of 6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine

There total 1 articles about 6-chloro-N⁴-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-amino-4,6-dichloro-2-methylpyrimidine (39906-04-2) + 3-chloro-aniline (108-42-9) → 6-chloro-N4-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine (1609009-27-9)

Guidance literature:

With hydrogenchloride; In 2-methyl-propan-1-ol; water; at 150 ℃; Microwave irradiation;

DOI:10.1021/jm401844c

Reference yield: 65.0%

6-chloro-N4-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine (1609009-27-9) → 7-chloro-3-(3'-chlorophenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (1609009-36-0)

Guidance literature:

With hydrogenchloride; sodium nitrite; In dichloromethane; water; at 20 ℃; for 0.5h;

DOI:10.1021/jm401844c

Reference yield:

6-chloro-N4-(3’-chlorophenyl)-2-methylpyrimidine-4,5-diamine (1609009-27-9) → 3-(3′-chlorophenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one (1609009-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite / water; dichloromethane / 0.5 h / 20 °C

2: sodium acetate / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With hydrogenchloride; sodium acetate; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm401844c

upstream raw materials:

5-amino-4,6-dichloro-2-methylpyrimidine

3-chloro-aniline

Downstream raw materials:

7-chloro-3-(3'-chlorophenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine

3-(3′-chlorophenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one