(2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride

Base Information

• Chemical Name: (2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride
• CAS No.: 25023-36-3
• Molecular Formula: C6H8 N2 O2
• Molecular Weight: 140.14
• Hs Code.: 2933290090
• European Community (EC) Number: 675-218-8,827-419-9
• Mol file: 25023-36-3.mol

Synonyms:(2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride;30163-87-2;2-(2-methyl-1H-imidazol-1-yl)acetic acid hydrochloride;2-(2-methylimidazol-1-yl)acetic acid;hydrochloride;2-(2-methyl-1H-imidazol-1-yl)aceticacid;2-Methyl-1H-imidazole-1-acetic Acid Hydrochloride;MFCD06801036;AKOS015844003;AS-69142;(2-Methyl-1h-imidazol-1-yl)acetic acid hcl;CS-0216380;EN300-41507;A12398;W16424;A877735;2-(2-METHYL-1H-IMIDAZOL-1-YL)ACETIC ACID HCL;F2130-0093;Z1171978830

Chemical Property of (2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride

Chemical Property:

• Vapor Pressure: 4.62E-06mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 367.9°Cat760mmHg
• Flash Point: 176.3°C
• PSA: 55.12000
• Density: 1.27g/cm³
• LogP: 0.27610
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 176.0352552
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Methyl-1H-imidazol-1-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CN1CC(=O)O.Cl

Technology Process of (2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride

There total 2 articles about (2-Methyl-1H-imidazol-1-yl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methylimidazol-1-yl)-acetic acid ethyl ester → 2-(2-methyl-1H-imidazol-1-yl)acetic acid (25023-36-3)

Guidance literature:

(2-methylimidazol-1-yl)-acetic acid ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=4;

Reference yield:

2-methylimidazole (693-98-1) + ethyl bromoacetate (105-36-2) → 2-(2-methyl-1H-imidazol-1-yl)acetic acid (25023-36-3)

Guidance literature:

2-methylimidazole; ethyl bromoacetate;

With water;

DOI:10.1111/cbdd.13767

Reference yield: 5.0%

Cyclohexyl isocyanide (931-53-3) + 2-chloro-benzaldehyde (89-98-5) + 2-(2-methyl-1H-imidazol-1-yl)acetic acid (25023-36-3) + 3-(1,3,4-oxadiazol-2-yl)aniline (5378-35-8) → N-(3-(1,3,4-oxadiazol-2-yl)phenyl)-N-(1-(2-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-(2-methyl-1H-imidazol-1-yl)acetamide (1448308-96-0)

Guidance literature:

upstream raw materials:

2-methylimidazole

ethyl bromoacetate

Downstream raw materials:

N-(3-(1,3,4-oxadiazol-2-yl)phenyl)-N-(1-(2-chlorophenyl)-2-(cyclohexylamino)-2-oxoethyl)-2-(2-methyl-1H-imidazol-1-yl)acetamide

Refernces

• 1、 -. "2-alkyl substituted imidazolyl diphosphonic acid compound as well as preparation method and application thereof". Paragraph 0079; 0082; 0083. . Retrieved 2017/07/20.