tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate
CAS No.:1286720-81-7
Molecular Formula:C₂₇H₄₀N₄O₆S₂
Molecular Weight:580.77
Hs Code.:

Synonyms:tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

There total 12 articles about tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₄₇N₃O₈S₂

: 1286720-81-7
tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: With hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 6h;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: 1286721-79-6
(S)-methyl 6-(1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

: 1286720-81-7
tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

1.2: 8 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 1 h / 75 °C

2.2: pH 3 - 4

3.1: triethylamine / tetrahydrofuran / 0 °C

4.1: hydroxylamine / tetrahydrofuran; methanol / 6 h / 20 °C

With hydroxylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: 1286721-19-4
(S)-tert-butyl 8-(6-methoxy-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonane-7-carboxylate

: 1286720-81-7
tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h / 20 °C

3.1: sodium hydroxide / ethanol; water / 1 h / 75 °C

3.2: pH 3 - 4

4.1: triethylamine / tetrahydrofuran / 0 °C

5.1: hydroxylamine / tetrahydrofuran; methanol / 6 h / 20 °C

With hydroxylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.08.045