(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

Base Information

Chemical Name:(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride
CAS No.:1286721-03-6
Molecular Formula:C₂₂H₃₂N₄O₄S₂*ClH
Molecular Weight:517.113
Hs Code.:

Synonyms:(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

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Chemical Property of (S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

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Technology Process of (S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

There total 12 articles about (S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1286720-81-7
tert-butyl (S)-1-((S)-8-(6-(hydroxyamino)-6-oxohexylcarbamoyl)-1,4-dithia-7-azaspiro[4.4]nonan-7-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1286721-03-6
(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: C₃₂H₄₇N₃O₈S₂

: 1286721-03-6
(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / tetrahydrofuran; methanol / 6 h / 20 °C

2: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; hydroxylamine; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1016/j.ejmech.2011.08.045

Reference yield:

: 1286721-79-6
(S)-methyl 6-(1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamido)hexanoate

: 1286721-03-6
(S)-7-((S)-2-amino-3-phenylpropanoyl)-N-(6-(hydroxyamino)-6-oxohexyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

1.2: 8 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 1 h / 75 °C

2.2: pH 3 - 4

3.1: triethylamine / tetrahydrofuran / 0 °C

4.1: hydroxylamine / tetrahydrofuran; methanol / 6 h / 20 °C

5.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; hydroxylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate;
DOI:10.1016/j.ejmech.2011.08.045