diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate
CAS No.:80014-80-8
Molecular Formula:C₂₉H₃₃N₅O₆
Molecular Weight:547.611
Hs Code.:

diethyl N-<2-methyl-4-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>prop-2-ynylamino>benzoyl>-L-glutamate

Synonyms:diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

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Chemical Property of diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

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Technology Process of diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

There total 5 articles about diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 80014-86-4
diethyl N-<2-methyl-4-(prop-2-ynylamino)benzoyl>-L-glutamate

: 80014-80-8
diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; for 48h; Ambient temperature;
DOI:10.1021/jm00154a007

Reference yield:

: 30459-70-2
2-methyl-4-nitrobenzoyl chloride

: 80014-80-8
diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / pyridine / toluene / 1.5 h / 0 - 25 °C

2: 81 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

3: 37 percent / 2,6-lutidine / N,N-dimethyl-acetamide / 48 h / Ambient temperature

4: 39 percent / CaCO₃ / N,N-dimethyl-acetamide / 48 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; toluene;
DOI:10.1021/jm00154a007

Reference yield:

: 1975-51-5
2-methyl-4-nitrobenzoic acid

: 80014-80-8
diethyl N-<2-methyl-4-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / Heating

2: 77 percent / pyridine / toluene / 1.5 h / 0 - 25 °C

3: 81 percent / H₂ / 10percent Pd/C / ethanol / 760 Torr

4: 37 percent / 2,6-lutidine / N,N-dimethyl-acetamide / 48 h / Ambient temperature

5: 39 percent / CaCO₃ / N,N-dimethyl-acetamide / 48 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; thionyl chloride; hydrogen; calcium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide; toluene;
DOI:10.1021/jm00154a007