1975-51-5Relevant articles and documents
Oxidation of 4-nitro-o-xylene with nitric acid using N-hydroxyphthalimide under phase transfer conditions
Wei, Song-Bo,Tang, Bo,Peng, Xin-Hua
, p. 580 - 585 (2015)
4-Nitro-o-xylene was selectively oxidized to 2-methyl-4-nitrobenzoic acid using dilute nitric acid as the oxidizing agent under atmospheric pressure. The oxidation of 4-nitro-o-xylene was effectively promoted by an addition of radical initiators. Under re
Metal-Free Aerobic Oxidation of Nitro-Substituted Alkylarenes to Carboxylic Acids or Benzyl Alcohols Promoted by NaOH
Fang, Kun,Li, Guijie,She, Yuanbin
, p. 8092 - 8103 (2018/06/25)
Efficient and selective aerobic oxidation of nitro-substituted alkylarenes to functional compounds is a fundamental process that remains a challenge. Here, we report a metal-free, efficient, and practical approach for the direct and selective aerobic oxidation of nitro-substituted alkylarenes to carboxylic acids or benzyl alcohols. This sustainable system uses O2 as clean oxidant in a cheap and green NaOH/EtOH mixture. The position and type of substituent critically affect the products. In addition, this sustainable protocol enabled gram-scale preparation of carboxylic acid and benzyl alcohol derivatives with high chemoselectivities. Finally, the reactions can be conducted in a pressure reactor, which can conserve oxygen and prevent solvent loss. The approach was conducive to environmental protection and potential industrial application.
Method for synthesis of 2-aldehyde-4-aminobenzoic acid
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Paragraph 0006, (2017/04/03)
The invention relates to a method for synthesis of 2-aldehyde-4-aminobenzoic acid. The method for synthesis of 2-aldehyde-4-aminobenzoic acid, which is provided by the invention, is simple and cheap, gentle in reaction condition in the preparation process, and high in yield.