Technology Process of 3-(3-(cyclobutyl(((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoic acid
There total 12 articles about 3-(3-(cyclobutyl(((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / ethanol / 23 h / Reflux
2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C
2.2: pH 7
3.1: toluene-4-sulfonic acid / 1.25 h
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice
4.2: 21 h
5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C
6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C
7.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 19 h / 20 °C
8.1: sodium cyanoborohydride; acetic acid; methanol / 72 h / 20 °C
9.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
9.2: pH 6
With
hydrogenchloride; methanol; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane;
toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; butan-1-ol;
- Guidance literature:
-
ethyl 3-(3-(cyclobutyl(((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate;
With
methanol; lithium hydroxide monohydrate;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
pH=6;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / ethanol / 23 h / Reflux
2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C
2.2: pH 7
3.1: toluene-4-sulfonic acid / 1.25 h
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice
4.2: 21 h
5.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C
6.1: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C
7.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 19 h / 20 °C
8.1: sodium cyanoborohydride; acetic acid; methanol / 72 h / 20 °C
9.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C
9.2: pH 6
With
hydrogenchloride; methanol; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane;
toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; butan-1-ol;
