14052-82-5Relevant articles and documents
Phosphoramidate protides of carbocyclic 2′,3′-dideoxy-2′, 3′-didehydro-7-deazaadenosine with potent activity against HIV and HBV
Gudmundsson, Kristjan S.,Wang, Zhicheng,Daluge, Susan M.,Johnson, Lance C.,Hazen, Richard,Condreay, Lynn D.,McGuigan, Christopher
, p. 1929 - 1937 (2004)
Synthesis of phosphoramidate protides of carbocyclic D- and L-2′,3′-dideoxy-2′,3′-didehydro-7-deazaadenosine by treatment of the nucleoside with phosphorochloridates in the presence of pyridine and t-BuMgCl is described. Several of these protides showed s
Synthesis of some pyrrolo[2,3-d]pyrimidine and 1,2,3-triazole isonucleosides
Talekar, Ratnakar R.,Wightman, Richard H.
, p. 3831 - 3842 (1997)
Nucleoside analogues 8, 9, 10 and 11, in which a pyrrolo[2,3-d]pyrimidine ring is linked to a 2-hydroxymethyl-3-hydtoxytetrahydrofuran have been prepared The azide 16 used as an intermediate in the mutes to these compounds also gave access to the 1,2,3-triazole isonucleosides 12 and 13.
4-chloro-7H-pyrrolo[2,3-d]pyrimidine synthetic method
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Paragraph 0054; 0056; 0059; 0061; 0062; 0065, (2018/09/11)
The invention discloses a 4-chloro-7H-pyrrolo[2,3-d]pyrimidine synthetic method. A compound is an important intermediate for synthesizing ruxolitinib and tofacitinib as a JAK inhibitor for treating rheumatoid arthritis. The 4-chloro-7H-pyrrolo[2,3-d]pyrimidine synthetic method comprises the following steps of by taking a compound I (4,6-dichloro-5-allyl pyrimidine) as a starting material, performing oxidation reaction on the compound I and ozone to produce a compound II; then performing nucleophilic substitution reaction on the compound II and triethyl orthoformate to produce a compound III; then performing nucleophilic substitution reaction on the compound III and ammonia gas to produce a compound IV; and finally, performing ring closing on the compound IV self in an acid environment to produce a compound V, i.e., 4-chloro-7H-pyrrolo[2,3-d]pyrimidine, wherein a synthetic route is shown as the following formula (described in the description). The synthetic method disclosed by the invention is cheap and available in raw materials, simple and short in synthetic route, low in cost, high in yield and easy in industrial production.
INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6
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, (2014/02/16)
Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is -H or -CH3; and Y is Formula (II) or Formula (III), wherein R