1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone
CAS No.:1600566-39-9
Molecular Formula:C₃₁H₂₆F₆N₂O₂
Molecular Weight:572.55
Hs Code.:

Synonyms:1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

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Chemical Property of 1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

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Technology Process of 1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

There total 6 articles about 1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25519-79-3
1-(4-benzoylpiperidin-1-yl)ethanone

: 1600562-93-3
6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline

: 1600566-39-9
1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: 6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline; With isopropylmagnesium chloride; In tetrahydrofuran; at -70 - 20 ℃; for 0.216667h; Inert atmosphere;

1-(4-benzoylpiperidin-1-yl)ethanone; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: 25519-80-6
4-(benzoyl)piperidine hydrochloride

: 1600566-39-9
1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.22 h / -70 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: Inert atmosphere

With isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1600566-39-9
1-(4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.1 h / -68 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C

2.2: 0.5 h / 20 °C

3.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C

4.1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / tert-butyl alcohol / 0.5 h / 150 °C / Microwave irradiation

5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.22 h / -70 - 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

5.3: Inert atmosphere

With copper(l) iodide; n-butyllithium; sodium azide; tributyl-amine; isopropylmagnesium chloride; diisopropylamine; sodium iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;